Fig. 5
From: Boiogito, a Kampo medicine, improves hydrarthrosis in a rat model of knee osteoarthritis
Effects of boiogito and indomethacin on joint pain in a rat model of knee osteoarthritis (OA). Joint pain was assessed by the weight ratio of the right (osteoarthritic) to left (contralateral control) hind limbs using an incapacitance tester. Rats with OA showed weight-bearing deficits associated with knee pain. Boiogito (n = 12) and indomethacin (n = 11) significantly alleviated weight-bearing deficits in rats with OA. Results are expressed as mean ± SE. ##P < 0.01 vs. sham-operated rats (Sham, n = 8), *P < 0.05, **P < 0.01 vs. non-treated control rats with OA (Con, n = 12)