Fig. 2

Effects of boiogito and indomethacin on hydrarthrosis in a rat model of knee osteoarthritis (OA). Rats with OA were given chow containing boiogito (1 or 2 %, n = 12) or indomethacin (Ind; 0.002 %, n = 11) for 4 weeks. Increased synovial fluid volume and interleukin-1β in the articular cavity were observed in rats with surgically induced OA. a: Synovial fluid volume in rats with OA was decreased by boiogito. b: The level of interleukin-1β in the articular cavity in rats with OA was reduced by boiogito and Ind. Results are expressed as mean ± standard error (SE). ^##P < 0.01 vs. sham-operated rats (Sham, n = 8), *P < 0.05, **P < 0.01 vs. non-treated control rats with OA (Con, n = 12)