Evaluation of the antiplasmodial properties of selected plants in southern Ethiopia

Table 6 Antimalarial activity of solvent fractions of A. integrifolia on parasitaemia level of P. berghei infected Swiss albino mice

Fraction type	Dose mg/kg/day	D4 post infection		P value
Fraction type	Dose mg/kg/day	% of Parasitaemia (M ± SEM)	% of inhibition (M ± SEM)	P value
Water	100	43.20 ± 1.65	9.72 ± 1.27	0.091
	200	42.40 ± 1.50^*a	11.29 ± 1.01	0.035
	400	36.60 ± 1.21^*a	23.44 ± 1.10	0.001
n-Butanol	100	42.20 ± 1.06^*a	11.80 ± 2.09	0.026
	200	39.80 ± 1.28^*a	17.16 ± 0.94	0.014
	400	35.80 ± 1.28^*a	29.80 ± 0.66	0.000
Chloroform	100	47.00 ± 1.41	3.68 ± 0.83	0.752
	200	46.20 ± 1.49	5.78 ± 11.69	0.494
	400	47.80 ± 1.39	9.80 ± 3.41	0.157
NC	0	49.20 ± 1.50	0.00 ± 0.00
PC	10	0.00 ± 0.00	100.00 ± 0.00

Values are expressed as M ± SEM; n = 5
NC negative control (0.2 mL of dH2O), PC positive control (Chloroquine), D4 day four
*P < 0.05
^acompared to negative control

ISSN: 2662-7671