Fig. 5

Representative photomicrographs of kidney cortex histopathology (400×). a: kidney cortex of mice in NC groups showing normal architecture; (b): kidney cortex of mice in MC groups after injection of STZ (120 mg/Kg) showing complete destruction of normal architecture of kidney cortex including shrunken proximal renal tubular cells with chromatin condensation, cytoplasm with vacuolation and cells with swelling and lysis; (c): kidney cortex of mice in PC groups; (d-f): kidney cortex of mice fed with Ac-, Al-, and En-MZPS at dosage of 800 mg/Kg showing mild architectural damage; (g-i): kidney cortex of mice fed with Ac-, Al-, and En-MZPS at dosage of 400 mg/Kg showing mild architectural damage with few showing abnormal structure; (j-l): kidney cortex of mice fed with Ac-, Al-, and En-MZPS at dosage of 200 mg/Kg showing almost normal histology similar to control mice