Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines

Table 4 IC₅₀ values and selectivity index (IS) of a normal cell line and different tumor cell lines treated with C. langsdorffii oleoresin or (-)-copalic acid and the positive controls, doxorubicin (DXR), (S)-(-)-camptothecin (CPT) and etoposide (VP16)

Cell lines	C. langsdorffii		(-)-copalic acid		DXR		CPT		VP16
	IC ₅₀ µg mL ⁻¹	IS	IC ₅₀ µg mL ⁻¹	IS	IC ₅₀ µg mL ⁻¹	IS	IC ₅₀ µg mL ⁻¹	IS	IC ₅₀ µg mL ⁻¹	IS
V79	365.90	-	107.30	-	7.83	-	19.61	-	45.90	-
U343	ND	-	222.50	0.48	0.70	11.18	5.71	3.44	2.18	21.05
U251	ND	-	275.20	0.38	16.28	0.46	11.14	1.76	42.97	1.06
M059J	ND	-	68.31	1.57	6.98	1.12	15.55	1.26	2.18	21.05
MCF 7	488.90	0.74	150.30	0.71	5.39	1.45	36.09	0.54	82.67	0.55
HepG2	ND		351.20	0.30	62.13	0.12	11.87	1.65	235.37	0.19
HeLa	ND		44.03	2.43	21.90	0.35	19.38	1.01	225.50	0.20
B16F10	ND		257.60	0.41	3.81	2.05	20.17	0.97	48.91	0.98

Normal cell line: Chinese hamster lung fibroblasts (V79). Tumor cell lines: murine melanoma (B16F10), human breast adenocarcinoma (MCF-7), human cervical adenocarcinoma (HeLa), human hepatocellular liver carcinoma (HepG2), and human glioblastoma (MO59J, U343 and U251). ND, not determined. The selective index is the ratio between the IC₅₀ values of the oleoresin or (-)-copalic acid on V79 cells and those found in the cancer cell lines

ISSN: 2662-7671