Table 1 Effects of S. crispus extracts on the number of crypts per focus on AOM-induced ACF in rat colons
Group | Number of foci | ACF | |||||
|---|---|---|---|---|---|---|---|
1 crypt | 2 crypts | 3 crypts | 4 crypts | >5 crypts | Total | Inhibition % | |
Cancer control group (AOM) | 26 ± 7.15 | 36 ± 8.4 | 31 ± 4.4 | 25 ± 1.4 | 32 ± 7.3 | 150 ± 21.0 | 0 |
AOM + 5-FU | 10 ± 2.1** | 9 ± 2.3** | 9 ± 2.6** | 5 ± 1.5** | 8 ± 2.6** | 41 ± 9.6** | 72.6 % |
AOM+ S. crispus (250 mg/kg) | 4 ± 1.4** | 11 ± 2.3** | 13 ± 0.5** | 8 ± 2.5** | 8 ± 2.4** | 44 ± 4.6** | 70.6 % |
AOM+ S. crispus (500 mg/kg) | 8 ± 0.5** | 10 ± 2.7** | 11 ± 2.1** | 8 ± 1.2** | 6 ± 1.2** | 43 ± 2** | 71.3 % |