Protective effect of Suxiao jiuxin pill, a traditional Chinese medicine, against acute myocardial ischemia in dogs

Lu, Zhiqiang; Zhang, Yanjun; Zhuang, Pengwei; Zhang, Jinbao; Zhou, Huifang; Zhang, Mixia; Yang, Xinpeng; Wang, Jinlei; Liu, Dan; Tong, Yongling

doi:10.1186/s12906-015-0908-9

BMC Complementary Medicine and Therapies

Table 4 Blood gas analysis parameters at pre-occlusion, pre-administration and post-administration (180 min)

From: Protective effect of Suxiao jiuxin pill, a traditional Chinese medicine, against acute myocardial ischemia in dogs

	Group	Pre-Occ	Pre-Adm	Post-Adm (min)
	Group	Pre-Occ	Pre-Adm	30	60	90	120	180
CvO₂ (vol %)	Sham	11.01 ± 4.84	11.3 ± 4.26	10.93 ± 4.44	8.73 ± 4.41	8.67 ± 3.81	8.05 ± 3.53	7.88 ± 3.27
	Model	11.38 ± 2.8	10.36 ± 4.1	9.24 ± 4.19	7.99 ± 3.64	6.57 ± 3.3	6.57 ± 3.35	5.43 ± 3.01
	SX-H	12.06 ± 3.2	11.32 ± 4.36	10.47 ± 2.44	9.64 ± 1.95	8.38 ± 1.68	8.12 ± 2.29	7.38 ± 2.55
	SX-M	12.67 ± 3.63	12.01 ± 3.8	10.76 ± 4.14	9.99 ± 4.27	8.94 ± 4.19	8.94 ± 4.66	8.35 ± 5.17
	SX-L	12.01 ± 2.82	9.53 ± 3.37	8.5 ± 3	8.81 ± 4.2	8.64 ± 3.31	7.47 ± 2.27	5.96 ± 2.73
	ISD	11.94 ± 1.21	11.44 ± 1.34	11.51 ± 2.16	10.31 ± 1.77	9.95 ± 2.65	9.78 ± 3.03	8.52 ± 3.42
CaO₂ (vol %)	Sham	19 ± 0.68	19.21 ± 0.41	18.99 ± 0.45	18.81 ± 0.47	18.82 ± 0.41	18.68 ± 0.64	18.74 ± 0.73
	Model	18.78 ± 1.2	18.32 ± 2.32	17.83 ± 1.02	17.4 ± 1.8	17.34 ± 2.04	17.14 ± 2.19	16.86 ± 2.07
	SX-H	19 ± 0.38	18.64 ± 0.53	18.46 ± 0.69	18.31 ± 0.78	18.2 ± 0.85	18.2 ± 0.58	17.81 ± 1.17
	SX-M	18.82 ± 0.43	18.54 ± 0.78	18.42 ± 0.88	18.22 ± 1.22	18.22 ± 1	18.09 ± 0.94	17.6 ± 1.18
	SX-L	18.77 ± 0.42	18.44 ± 0.76	18.03 ± 0.97	17.79 ± 0.84	17.53 ± 0.9	17.22 ± 1.03	16.53 ± 1.24
	ISD	18.45 ± 0.91	18.22 ± 0.71	18.04 ± 0.56	18.17 ± 0.96	17.77 ± 0.95	17.74 ± 0.77	17.61 ± 1.41
O₂ Extr (%)	Sham	0.36 ± 0.22	0.37 ± 0.21	0.37 ± 0.21	0.5 ± 0.25	0.5 ± 0.2	0.58 ± 0.21	0.58 ± 0.21
	Model	0.42 ± 0.14	0.47 ± 0.19	0.53 ± 0.21	0.59 ± 0.17	0.67 ± 0.13	0.66 ± 0.16	0.71 ± 0.15
	SX-H	0.36 ± 0.17	0.39 ± 0.24	0.43 ± 0.13	0.47 ± 0.12	0.54 ± 0.09*	0.55 ± 0.13*	0.59 ± 0.11*
	SX-M	0.33 ± 0.2	0.35 ± 0.22	0.42 ± 0.23	0.46 ± 0.23	0.51 ± 0.23	0.51 ± 0.25	0.53 ± 0.28
	SX-L	0.36 ± 0.16	0.48 ± 0.19	0.53 ± 0.16	0.51 ± 0.22	0.51 ± 0.16	0.57 ± 0.11	0.64 ± 0.15
	ISD	0.35 ± 0.07	0.37 ± 0.09	0.36 ± 0.13	0.43 ± 0.1	0.44 ± 0.14*	0.45 ± 0.17*	0.51 ± 0.2*
MVO₂ (ml/min · 100 g)	Sham	9.72 ± 5.64	10.15 ± 4.05	9.95 ± 4.4	13.95 ± 7.14	15.5 ± 8.73	17.94 ± 9.83	18.52 ± 7.22
	Model	10.79 ± 5.28	15.53 ± 10.01	16.58 ± 8.45	19.24 ± 7.82	20.64 ± 7.62	23.54 ± 8.18	26.36 ± 6.74
	SX-H	9.92 ± 4.5	11.05 ± 7.99	10.81 ± 2.06	13.36 ± 3.85	15.75 ± 5.73	16.16 ± 7.54	19.8 ± 5.45
	SX-M	7.79 ± 2.51	9.13 ± 4.83	9.36 ± 2.39	9.93 ± 3.8	13.05 ± 7.04	16.47 ± 10.73	18.03 ± 8.71
	SX-L	8.75 ± 5.14	11.31 ± 3.73	12.44 ± 2.06	13.67 ± 5.81	14.82 ± 4.77	15.62 ± 3.61	17.05 ± 4.04
	ISD	11.7 ± 1.36	13.59 ± 4.41	11.18 ± 3.09	14.51 ± 2.54	14.31 ± 3.46	16.22 ± 5.67	21.92 ± 12.7

All data were expressed as mean ± S.D. CvO₂ oxygen content of venous, CaO₂ oxygen content of arterial, O₂ Extr oxygen extraction ratio, MVO₂ myocardial oxygen consumption. *P < 0.05 vs. model group

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