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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer’s disease

Fig. 2

Effect of CDS on Aβ25–35-induced memory deficit in the Morris water maze. a The swimming speed did not differ between treatment groups over time. b Changes in escape latency to the platform during acquisition trials in rats treated with vehicle(Veh), Aβ25–35 + Veh, Aβ25–35 + CDS (130 mg/kg, 260 mg/kg and 520 mg/kg) or Aβ25–35 + Donepezil (0.5 mg/kg). Aβ25–35 (10 μg/side) significantly increased escape latency for 2 days relative to other groups. c, d. Effects of Aβ25–35 with or without treatment on the swimming distance (c) and duration (d) in the target quadrant in the probe trial performed 24 h after the last training trial. Aβ25–35-treated rats displayed decreases in both the swimming distance and duration; these were reversed by CDS (520 mg/kg) and donpezil. Values shown are means ± SD. n = 8 ~ 9; # P < 0.05 vs. Veh alone; * P < 0.05, ** P < 0.01 vs. Aβ25–35 + Veh

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