Anti-diabetic potential of Catharanthus roseus Linn. and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats

Table 3 Effect of ethanolic extract of c. roseus on some biochemical parameter on rats

Dose mg/kg	GLU mg/dl	CHOL mg/dl	CRE Umol/L	ALP IU/L	ALT IU/L	AST IU/L	GST IU/L	BUN mg/dl
Normal Control Group	98.9 ± 2.28	59.12 ± 5.08	107.24 ± 4.08	102.4 ± 3.81	56.82 ± 5.04	87.28 ± 5.83	0.59 ± 0.05	38.40 ± 2.36
Diabetic Control Group	256.32 ± 8.64	117.34 ± 2.20	196.74 ± 2.84	286.21 ± 5.34	134.20 ± 7.41	37.43 ± 4.59	0.45 ± 0.06	116.2 ± 1.24
Treated with 100 mg/kg C. roseus	189.42 ± 11.2*	92.49 ± 7.17*	168.26 ± 6.23*	185.36 ± 4.32*	98.64 ± 8.80*	116.16 ± 4.51*	0.44 ± 0.07	86.26 ± 2.49*
Treated with 200 mg/kg C. roseus	153.34 ± 6.72**	85.43 ± 6.61**	132.41 ± 6.31**	150.42 ± 4.78**	81.38 ± 4.86**	125.29 ± 5.09	0.44 ± 0.07	65.41 ± 5.23**
Treated with 100 mg/kg Metformin	135.56 ± 9.72**	68.04 ± 5.80**	127.74 ± 3.16**	126.46 ± 3.68**	76.44 ± 4.72**	129.52 ± 3.96**	0.44 ± 0.07	45.72 ± 4.84**

Results are mean ± SD, n05
GLU glucose, CHOL cholesterol, CRE creatinine, ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, GST Glutathione S-transferase, BUN blood urea nitrogen
Values are expressed as mean ± SD for six animals in each group. *Level of significance p < 0.05, **Level of significance p < 0.01

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