Study | Animal species | AD model | Main experimental groups | Method of administration | Time of ginsenoside administration | Anesthetic agent | Duration of supplementation |
---|---|---|---|---|---|---|---|
Wang YC et al. 2014 | Male Kunming mice | chronic restraint stress (CRS) | Control r(n = 15) | Ig | Immediately after injury | chloral hydrate | 8 weeks |
CRS + distilled water (n = 15) | |||||||
CRS +2.0 mg/kg Rg1 (n = 15) | |||||||
CRS +5.0 mg Rg1 /kg r(n = 15) | |||||||
Bombi Lee et al. 2013 | Male SD rats | LPS injected into the bilateral lateral cerebral ventricle | LPS-injected plus saline (n = 6) | Ip | Immediately after injury | pentobarbital | 3 weeks |
LPS-injected plus 10 mg/kg Rg3 (n = 6) | |||||||
LPS-injected plus 20 mg/kg Rg3 (n = 6) | |||||||
LPS-injected plus 30 mg/kg Rg3 (n = 6) | |||||||
Song XY et al. 2013 | Male SD rats | OKA injected into the right lateral cerebral ventricle | OKA-injected plus distilled water (n = 12) | Ig | A week before OKA microinjected | chloral hydrate | 25 days |
OKA-injected plus 5 mg/kg Rg1 (n = 12) | |||||||
OKA-injected plus 10 mg/kg Rg1 (n = 12) | |||||||
OKA-injected plus 20 mg/kg Rg1 (n = 12) | |||||||
Quan QK et al. 2013 | Male SD rats | Aβ1–42 injected into Both Hippocampal CA1 regions | Aβ1–42 injected plus normal saline (n = 10) | Ip | 5 days after Aβ1–42 injected | chloral hydrate | 4 weeks |
Aβ1–42 injected plus 10 mg/kg Rg1 (n = 10) | |||||||
Zhao HH et al. 2012 | Female ICR mice | Oral AlCl3 in drinking water | Al exposure plus distilled water (n = 8) | Ig | 6 month after AlCl3 oraled | pentobarbital | 4 months |
Al exposure plus 20 mg/kg Rb1 (n = 8) | |||||||
Wang YL et al. 2011 | Male Wistar rats | Aβ1-40 into the right lateral cerebral ventricle | Aβ1-42 plus saline (n = 10) | Ip | 2 weeks after AlCl3 orale | not clear | 4 weeks |
A1-42 plus 10 mg/kg Rg2 (n = 10) | |||||||
Zhang X et al. 2012 | Female Wistar rats | Ovariectomized (OVX) & D-gal injected intraperitoneally | OVX, D-gal plus vehicle | Ip | Immediately after injury | chloral hydrate | 6 weeks |
OVX, D-gal plus 5 mg/kg Rg1 (n = 8) | |||||||
OVX, D-gal plus 10 mg/kg Rg1 (n = 8) | |||||||
OVX, D-gal plus 20 mg/kg Rg1 (n = 8) | |||||||
Chu SH et al. 2014 | Wistar rats | Streptozotocin (STZ) injected into the bilateral lateral cerebral ventricle | STZ plus physiological saline (n = 12) | Ig | 2 days after STZ injected | not clear | 4 weeks |
STZ plus 5 mg/kg Rg5 (n = 12) | |||||||
STZ plus 10 mg/kg Rg5 (n = 12) | |||||||
STZ plus 20 mg/kg Rg5 (n = 12) | |||||||
Zhou LP et al. 2011 | Female C57BL/6 mice | Ovariectomized (OVX) & Aβ25-35 injected into the lateral cerebral ventricle | OVX, Aβ 25–35 plus Rg1 10 mg/kg (n = 10) | Ip | 10 days later | chloral hydrate | 14 days |
Wang XY et al. 2001 | Male Kunming mice | Aβ25–35 injected into the lateral cerebral ventricle | Aβ25-35 plus physiological saline (n = 10) | Ip | 1 days after Aβ25-35 injected | diethyl ether | 10 days |
Aβ25-35 plus 5 mg/kg Rg5 (n = 10) | |||||||
Aβ25-35 plus 10 mg/kg Rg5 (n = 10) | |||||||
Wu W et al. 2011 | Male SD rats | fimbria/fornix transection | fimbria/fornix transection(15) | Ip | 14 days after fimbria/fornix transection | chloral hydrate | 4 weeks |
fimbria/fornix transection plus 10 mg/kg Rg1 (n = 15) | |||||||
Zang Y et al. 2010 | Male & female Wistar rats | Aβ25–35 injected into Both Hippocampal regions | Aβ25-35 plus physiological saline (n = 12) | Ip | 15 days before Aβ25-35 injected | chloral hydrate | 5 weeks |
Aβ25-35 plus 3 mg/kg Rg2 (n = 12) | |||||||
Aβ25-35 plus 6 mg/kg Rg2 (n = 12) | |||||||
Aβ25-35 plus 12 mg/kg Rg2 (n = 12) |