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Table 2 Characteristics of included studies

From: The impact of ginsenosides on cognitive deficits in experimental animal studies of Alzheimer’s disease: a systematic review

Study

Animal species

AD model

Main experimental groups

Method of administration

Time of ginsenoside administration

Anesthetic agent

Duration of supplementation

Wang YC et al. 2014

Male Kunming mice

chronic restraint stress (CRS)

Control r(n = 15)

Ig

Immediately after injury

chloral hydrate

8 weeks

CRS + distilled water (n = 15)

CRS +2.0 mg/kg Rg1 (n = 15)

CRS +5.0 mg Rg1 /kg r(n = 15)

Bombi Lee et al. 2013

Male SD rats

LPS injected into the bilateral lateral cerebral ventricle

LPS-injected plus saline (n = 6)

Ip

Immediately after injury

pentobarbital

3 weeks

LPS-injected plus 10 mg/kg Rg3 (n = 6)

LPS-injected plus 20 mg/kg Rg3 (n = 6)

LPS-injected plus 30 mg/kg Rg3 (n = 6)

Song XY et al. 2013

Male SD rats

OKA injected into the right lateral cerebral ventricle

OKA-injected plus distilled water (n = 12)

Ig

A week before OKA microinjected

chloral hydrate

25 days

OKA-injected plus 5 mg/kg Rg1 (n = 12)

OKA-injected plus 10 mg/kg Rg1 (n = 12)

OKA-injected plus 20 mg/kg Rg1 (n = 12)

Quan QK et al. 2013

Male SD rats

Aβ1–42 injected into Both Hippocampal CA1 regions

Aβ1–42 injected plus normal saline (n = 10)

Ip

5 days after Aβ1–42 injected

chloral hydrate

4 weeks

Aβ1–42 injected plus 10 mg/kg Rg1 (n = 10)

Zhao HH et al. 2012

Female ICR mice

Oral AlCl3 in drinking water

Al exposure plus distilled water (n = 8)

Ig

6 month after AlCl3 oraled

pentobarbital

4 months

Al exposure plus 20 mg/kg Rb1 (n = 8)

Wang YL et al. 2011

Male Wistar rats

Aβ1-40 into the right lateral cerebral ventricle

Aβ1-42 plus saline (n = 10)

Ip

2 weeks after AlCl3 orale

not clear

4 weeks

A1-42 plus 10 mg/kg Rg2 (n = 10)

Zhang X et al. 2012

Female Wistar rats

Ovariectomized (OVX) & D-gal injected intraperitoneally

OVX, D-gal plus vehicle

Ip

Immediately after injury

chloral hydrate

6 weeks

OVX, D-gal plus 5 mg/kg Rg1 (n = 8)

OVX, D-gal plus 10 mg/kg Rg1 (n = 8)

OVX, D-gal plus 20 mg/kg Rg1 (n = 8)

Chu SH et al. 2014

Wistar rats

Streptozotocin (STZ) injected into the bilateral lateral cerebral ventricle

STZ plus physiological saline (n = 12)

Ig

2 days after STZ injected

not clear

4 weeks

STZ plus 5 mg/kg Rg5 (n = 12)

STZ plus 10 mg/kg Rg5 (n = 12)

STZ plus 20 mg/kg Rg5 (n = 12)

Zhou LP et al. 2011

Female C57BL/6 mice

Ovariectomized (OVX) & Aβ25-35 injected into the lateral cerebral ventricle

OVX, Aβ 25–35 plus Rg1 10 mg/kg (n = 10)

Ip

10 days later

chloral hydrate

14 days

Wang XY et al. 2001

Male Kunming mice

25–35 injected into the lateral cerebral ventricle

Aβ25-35 plus physiological saline (n = 10)

Ip

1 days after Aβ25-35 injected

diethyl ether

10 days

Aβ25-35 plus 5 mg/kg Rg5 (n = 10)

Aβ25-35 plus 10 mg/kg Rg5 (n = 10)

Wu W et al. 2011

Male SD rats

fimbria/fornix transection

fimbria/fornix transection(15)

Ip

14 days after fimbria/fornix transection

chloral hydrate

4 weeks

fimbria/fornix transection plus 10 mg/kg Rg1 (n = 15)

Zang Y et al. 2010

Male & female Wistar rats

25–35 injected into Both Hippocampal regions

Aβ25-35 plus physiological saline (n = 12)

Ip

15 days before Aβ25-35 injected

chloral hydrate

5 weeks

Aβ25-35 plus 3 mg/kg Rg2 (n = 12)

Aβ25-35 plus 6 mg/kg Rg2 (n = 12)

Aβ25-35 plus 12 mg/kg Rg2 (n = 12)

  1. Ig intragastrically, Ip intraperitoneally