Table 5 Effects of the subchronic oral administration of OS-EL on organ weights in Sprague Dawley rats
Organ weight (g) | Control water | OS-EL (mg/kg) 250 | 500 | 1000 |
|---|---|---|---|---|
Female rats | ||||
Liver | 7.95 ± 0.35 | 7.36 ± 0.38 | 8.06 ± 0.56 | 8.75 ± 0.39 |
Right kidney | 0.66 ± 0.07 | 0.69 ± 0.06 | 0.75 ± 0.03 | 0.73 ± 0.03 |
Left kidney | 0.69 ± 0.05 | 0.66 ± 0.03 | 0.72 ± 0.03 | 0.68 ± 0.02 |
Right ovarie | 0.09 ± 0.02 | 0.07 ± 0.00 | 0.07 ± 0.00 | 0.06 ± 0.00 |
Left ovarie | 0.08 ± 0.01 | 0.0625 ± 0.00 | 0.06 ± 0.00 | 0.06 ± 0.01 |
Uterus | 0.45 ± 0.04 | 0.52 ± 0.04 | 0.49 ± 0.04 | 0.54 ± 0.04 |
Brain | 1.71 ± 0.00 | 1.75 ± 0.03 | 1.69 ± 0.05 | 1.54 ± 0.13 |
Spleen | 0.61 ± 0.04 | 0.52 ± 0.03 | 0.65 ± 0.09 | 0.59 ± 0.01 |
Lung | 1.60 ± 0.09 | 1.28 ± 0.06 | 1.46 ± 0.149 | 1.36 ± 0.08 |
Right adrenal gland | 0.06 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 |
Left adrenal gland | 0.06 ± 0.01 | 0.05 ± 0.00 | 0.04 ± 0.00 | 0.05 ± 0.00 |
Full stomach | 6.47 ± 0.36 | 6.78 ± 0.89 | 7.66 ± 1.03 | 7.73 ± 0.42 |
Empty stomach | 1.38 ± 0.05 | 1.18 ± 0.08 | 1.245 ± 0.09 | 1.41 ± 0.05 |
Gut | 11.62 ± 0.68 | 11.47 ± 0.37 | 12.3 ± 0.56 | 11.1 ± 0.44 |
Empty gut | 7.37 ± 0.36 | 6.47 ± 0.42 | 7.29 ± 0.25 | 7.74 ± 0.16 |
Thymus | 0.26 ± 0.04 | 0.23 ± 0.00 | 0.29 ± 0.02 | 0.28 ± 0.04 |
Heart | 0.83 ± 0.04 | 0.84 ± 0.03 | 0.76 ± 0.05 | 0.75 ± 0.03 |
Male rats | ||||
Liver | 7.44 ± 0.13 | 8.58 ± 0.49 | 8.51 ± 0.48 | 8.00 ± 0.19 |
Right kidney | 0.88 ± 0.03 | 1.13 ± 0.04 | 1.02 ± 0.05 | 0.96 ± 0.05 |
Left kidney | 0.87 ± 0.02 | 0.92 ± 0.02 | 0.89 ± 0.03 | 0.95 ± 0.03 |
Right testes | 1.32 ± 0.04 | 1.26 ± 0.02 | 1.33 ± 0.04 | 1.34 ± 0.04 |
Left testes | 1.29 ± 0.05 | 1.26 ± 0.03 | 1.29 ± 0.05 | 1.38 ± 0.05 |
Brain | 1.81 ± 0.03 | 1.86 ± 0.05 | 1.86 ± 0.10 | 1.83 ± 0.01 |
Spleen | 0.53 ± 0.03 | 0.71 ± 0.01 | 0.65 ± 0.07 | 0.614 ± 0.04 |
Lung | 1.58 ± 0.09 | 1.58 ± 0.04 | 1.57 ± 0.10 | 1.38 ± 0.05 |
Right adrenal gland | 0.05 ± 0.00 | 0.06 ± 0.01 | 0.03 ± 0.00 | 0.04 ± 0.00 |
Left adrenal gland | 0.04 ± 0.00 | 0.04 ± 0.00 | 0.04 ± 0.00 | 0.04 ± 0.00 |
Full stomach | 2.43 ± 0.29 | 2.78 ± 0.34 | 2.83 ± 0.23 | 2.6 ± 0.36 |
Empty stomach | 1.22 ± 0.04 | 1.30 ± 0.03 | 1.35 ± 0.08 | 1.31 ± 0.03 |
Gut | 12.1 ± 0.36 | 11.97 ± 0.60 | 12 ± 0.36 | 12.14 ± 0.41 |
Empty gut | 7.44 ± 1.65 | 6.8 ± 0.50 | 6.16 ± 0.32 | 7.00 ± 0.66 |
Thymus | 0.24 ± 0.03 | 0.37 ± 0.02 | 0.35 ± 0.07 | 0.30 ± 0.04 |
Heart | 0.84 ± 0.06 | 0.91 ± 0.00 | 0.88 ± 0.07 | 0.79 ± 0.01 |