Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats

Table 1 Chemopreventive effect of hydro-methanol Rumex abyssinicus rhizome extract on the post-initiation of aberrant crypt foci (ACF) in six weeks DMH treatment induced colon carcinogenesis

Animal group	N	Treatment	AC	ACF	Crypt multiplicity
Animal group	N	Treatment	Mean ± SD	Mean ± SD	Mean ± SD
Group I	5	Saline	0	0	0
Group II	5	DMH	103.60 ± 21.04	24.80 ± 3.56	4.17 ± 0.64
Group III	5	PI 250 mg/kg + DMH	41.40 ± 9.66^ac	11 ± 3.00^ac	3.83 ± 0.39^NSc
Group IV	5	PI 500 mg/kg + DMH	33.20 ± 6.14^bc	8.80 ± 1.64^ac	3.78 ± 0.19^NSc

AC aberrant crypt, ACF aberrant crypt foci, crypt multiplicity the mean total of AC counted/mean total of ACF, DMH 1,2-dimethylhydrazine, N number of rats, PI post-initiation, SD standard deviation
^{a, b, NS}are all P-values where ^a< 0.001, ^b< 0.0001 and ^NS is not statistically significant
^cPost-initiation 250 mg/kg OR post-initiation 500 mg/kg versus DMH

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