TY - JOUR AU - Shih, Chung-Hung AU - Lin, Yu-Jing AU - Chen, Chi-Ming AU - Ko, Wun-Chang PY - 2015 DA - 2015/10/05 TI - Butylidenephthalide antagonizes cromakalim-induced systolic pressure reduction in conscious normotensive rats JO - BMC Complementary and Alternative Medicine SP - 344 VL - 15 IS - 1 AB - Butylidenephthalide (Bdph), a main constituent of Ligusticum chuanxiong Hort., was reported to have selective antianginal effect without changing blood pressure in conscious rat. Recently, we have observed that Bdph antagonized cromakalim, an ATP-dependent K+ channel opener, in guinea-pig trachea. Thus, we were interested in investigating whether Bdph at the dose without changing blood pressure antagonized cromakalim-induced systolic pressure reduction in conscious rats. SN - 1472-6882 UR - https://doi.org/10.1186/s12906-015-0877-z DO - 10.1186/s12906-015-0877-z ID - Shih2015 ER -