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Table 1 Cytotoxic activity of different solvent extracts of P. tetrastromatica, C. racemosa and T. ornata in human adenocarcinoma MCF-7 cells and the human non-tumourigenic 184B5 cells

From: Antioxidant and cytotoxic activities of three species of tropical seaweeds

Extracts MCF-7 cells IC50 (μg/mL) 184B5 cells IC20 (μg/mL)
P. tetrastromatica C. racemosa T. ornata P. tetrastromatica C. racemosa T. ornata
Hexane 130.0 ± 1.72 ND 240.0 ± 1.89 280.5 ± 1.34 ND ND
Dichloromethane (DCM) ND ND ND ND ND ND
Ethyl acetate (EA) ND ND ND ND ND ND
Acetone ND 100.0 ± 2.41 480.5 ± 2.27 ND 240.0 ± 1.26 ND
Methanol ND 60.0 ± 1.47 60.0 ± 1.14 ND 150.5 ± 1.48 950.0 ± 0.62
  1. Cytotoxic activity is expressed as IC50 (μg/mL) ± SD (n = 3) and IC50 (μg/mL) ± SD (n = 3) for MCF-7 and 184B5 cells, respectively, which is the concentration of extract at which 50 % of cell growth was inhibited relative to cells incubated in the presence of 0.1 % DMSO vehicle control. MCF-7 and 184B5 cells were treated with doxorubicin as a positive control. The drug showed IC50 values at 0.21 ± 1.25 μg/ml and 0.02 ± 1.97 μg/ml in MCF-7 and 184B5 cells, respectively
  2. ND: Not detected