Fig. 2
Effect of harpagoside on hypoxia-induced inflammatory gene expression (TNF-α, COX-2) of microglial cells. Three hours’ hypoxia stimulates microglial cells TNF-α and COX-2 genes expression. The maximal effect on COX-2 gene occurred at 6 h’ culture; while for the TNF-α gene, its maximal effect was at 0 h’ culture. The pre-incubation of 10−8 M harpagoside again can inhibit these effects (n = 4). Note: *: p < 0.05