Cell lines | Tested samples, IC50 values and degrees of resistance (in bracket) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Crude extracts and IC50 values (μg/mL) | IC50 values of compounds (μM) | IC50 values of doxorubicin (μM) | |||||||
NPB | NPL | 1 | 2 | 3 | 4 | 5 | 6 | ||
CCRF-CEM | 14.62 ± 1.23 | 25.84 ± 2.16 | >82.92 | >243.90 | >170.94 | 28.15 ± 1.32 | 25.08 ± 2.48 | 77.10 ± 5.87 | 0.20 ± 0.06 |
CEM/ADR5000 | 11.56 ± 0.85 (0.80) | 25.55 ± 1.63 (0.99) | >82.92 (n.a) | >243.90 (n.a) | >170.94 (n.a) | 57.43 ± 3.67 (2.04) | 39.87 ± 2.91 (1.59) | >80.29 (>1.04) | 195.12 ± 14.30 (975.60) |
MDA-MB231 | 37.00 ± 2.91 | 64.75 ± 5.08 | >82.92 | >243.90 | >170.94 | 19.90 ± 1.45 | 97.64 ± 7.60 | >80.29 | 1.10 ± 0.28 |
MDA-MB231/BCRP | 19.79 ± 2.13 (0.53) | 59.55 ± 4.21 (0.92) | >82.92 (n.a) | >243.90 (n.a) | >170.94 (n.a) | 22.93 ± 1.64 (1.15) | 95.59 ± 8.17 (0.98) | 78.26 ± 6.22 (<0.97) | 7.83 ± 0.47 (7.12) |
HCT116 (p53+/+) | 16.19 ± 1.16 | 32.78 ± 2.67 | >82.92 | >243.90 | >170.94 | 73.65 ± 5.67 | 63.77 ± 4.61 | >80.29 | 1.41 ± 0.29 |
HCT116 (p53−/−) | 8.70 ± 0.68 (0.54) | 19.39 ± 1.34 (0.59) | >82.92 (n.a) | >243.90 (n.a) | >170.94 (n.a) | >175.36 (>2.38) | 47.03 ± 4.94 (0.74) | >80.29 (n.a) | 4.06 ± 0.07 (2.88) |
U87MG | 69.44 ± 4.34 | >40 | >82.92 | >243.90 | >170.94 | 76.59 ± 4.92 | 55.64 ± 3.73 | >80.29 | 1.06 ± 0.15 |
U87MG.ΔEGFR | 32.78 ± 2.79 (0.47) | 63.90 ± 4.77 (>1.60) | >82.92 (n.a) | >243.90 (n.a) | >170.94 (n.a) | 28.45 ± 2.06 (0.37) | 47.59 ± 3.29 (0.86) | >80.29 (n.a) | 6.11 ± 0.57(5.76) |
AML12 | >40 | >40 | >82.92 | >243.90 | >170.94 | >175.36 | >102.56 | >80.29 | >73.59 |