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Table 4 Effect of methanol extract of P. foetida on Pylorus-ligated rats

From: Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India

Treatment Mean ulcer Index (SEM) % Protection Volume (ml) of gastric secretion Free Acidity (Eq/l/100gm) Total Acidity (Eq/l/100gm) pH
Group 1 Normal Control (Distl. Water, 5 ml/kg, p.o.) 0.33 ± 0.11 - 1.52 ± 0.49 71.97 ± 1.04 83.23 ± 0.68 3.65 ± 0.11
Group 2 Ulcer Control (Distl. Water, 5 ml/kg, p.o.) 7.00 ± 0.63***c - 7.40 ± 0.61***c 88.17 ± 2.14***c 130.17 ± 6.41***c 2.38 ± 0.19***c
Group 3 Methanol extract (150 mg/kg, p.o.) 1.11 ± 0.46*** 84 2.20 ± 0.35*** 50.17 ± 5.12*** 60.33 ± 3.20*** 5.42 ± 5.50***
Group 4 Cimetidine (8 mg/kg, p. o.) 1.00 ± 0.23*** 85 1.88 ± 0.22 *** 36.00 ± 5.29*** 44.00 ± 1.13*** 7.42 ± 0.15 ***
  1. Data were expressed as mean ± Standard Error Mean (SEM), where n=6 in each group. Differences were considered significant at ***P<0.001 when compared control group vs ulcer control group (c) and Test groups vs ulcer control group. For numerical results, one-way analysis of variance (ANOVA) with Tukey-Kramer Multiple Comparison post tests were performed using GraphPad InStat Version 3 (GraphPad Software)