Skip to main content
Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: TRPV1 channel inhibition contributes to the antinociceptive effects of Croton macrostachyus extract in mice

Fig. 5

Effect of oral administration of the methanol/methylene chloride extract of the stem bark of Croton macrostachyus (MECM, 500 mg/kg, po) on the spontaneous pain induced by capsaicin. Panel (a) shows the time course effect of MECM in different groups of animals. Panel (b) presents the effect of rimonabant (SR 141716, 10 mg/kg, po) on the analgesic activity of MECM and WIN 55212–2 (Win, 3 mg/kg, ip) on nociception induced by capsaicin. MECM was given 1 h before intraplantar injection of capsaicin while rimonabant (10 mg/kg, p.o) was given per os 30 min before Win and MECM. V = vehicle, cap = capsaicin, capz = capsazepine, ext = extract. N = 4 (Vcap) to 7 mice per group. **p < 0.01, ***p < 0.001 significantly different compared to respective controls. # p < 0.01 significantly different compared to the same treatment without rimonabant

Back to article page