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Table 3 Anti-trypanosomal activity of crude methanol leaf extract of D. abyssinica on parasitemia of mice infected with T. congolense

From: In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense

Rx D(mg/kg)    Parasitemia level (log number/ml)   
   D12 D14 D16 D18 D20 D22 D24 D26
MOH 250 7.08 ± .16 6.84 ± .25bcd 6.24 ± .25bcd 3.30 ± .13bcd 1.08 ± 2.55a 2.16 ± 2.96a 4.38 ± 2.45bcd 5.52 ± .16
  200 7.02 ± .16 6.78 ± .16bcd 6.48 ± .16bcd 5.94 ± .13 5.58 ± .16 5.76 ± .25 6.00 ± .21 6.12 ± .34
  150 7.02 ± .27 7.20 ± .3.7 7.32 ± .27 7.14 ± .25 7.26 ± .25 7.44 ± .25 7.56 ± .25 7.68 ± .34
  100 7.08 ± .16 7.32 ± .16 7.74 ± .25 7.98 ± .34 8.10 ± .37 8.28 ± .34 8.22 ± .27 8.40 ± .21
DA 28 7.08 ± .54 .00 ± .00 .00 ± .00 .00 ± .00 .00 ± .00 .00 ± .00 1.08 ± 1.0 2.16 ± 1.32
DMSO - 7.08 ± .16 7.26 ± .25 7.48 ± .30 7.74 ± .25 7.74 ± .13 8.04 ± .25 8.04 ± .25 8.46 ± .25
  1. Values are mean ± SD; N = 5; p < 0.05; acompared to all but DA; bcompared to 150 mg/kg; ccompared to 100 mg/kg; dcompared to DMSO
  2. MOH Methanol extract, Rx Treatment, D Dose, DA Diminzene aceturate, DMSO Dimethylsulfoxide, D Day, D12 Day of treatment initiation