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Table 3 Anti-trypanosomal activity of crude methanol leaf extract of D. abyssinica on parasitemia of mice infected with T. congolense

From: In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense

Rx

D(mg/kg)

  

Parasitemia level (log number/ml)

  
  

D12

D14

D16

D18

D20

D22

D24

D26

MOH

250

7.08 ± .16

6.84 ± .25bcd

6.24 ± .25bcd

3.30 ± .13bcd

1.08 ± 2.55a

2.16 ± 2.96a

4.38 ± 2.45bcd

5.52 ± .16

 

200

7.02 ± .16

6.78 ± .16bcd

6.48 ± .16bcd

5.94 ± .13

5.58 ± .16

5.76 ± .25

6.00 ± .21

6.12 ± .34

 

150

7.02 ± .27

7.20 ± .3.7

7.32 ± .27

7.14 ± .25

7.26 ± .25

7.44 ± .25

7.56 ± .25

7.68 ± .34

 

100

7.08 ± .16

7.32 ± .16

7.74 ± .25

7.98 ± .34

8.10 ± .37

8.28 ± .34

8.22 ± .27

8.40 ± .21

DA

28

7.08 ± .54

.00 ± .00

.00 ± .00

.00 ± .00

.00 ± .00

.00 ± .00

1.08 ± 1.0

2.16 ± 1.32

DMSO

-

7.08 ± .16

7.26 ± .25

7.48 ± .30

7.74 ± .25

7.74 ± .13

8.04 ± .25

8.04 ± .25

8.46 ± .25

  1. Values are mean ± SD; N = 5; p < 0.05; acompared to all but DA; bcompared to 150 mg/kg; ccompared to 100 mg/kg; dcompared to DMSO
  2. MOH Methanol extract, Rx Treatment, D Dose, DA Diminzene aceturate, DMSO Dimethylsulfoxide, D Day, D12 Day of treatment initiation