In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense

Table 2 In vivo anti-trypanosomal activity of dichloromethane crude leaf extract of D. abyssinica on parasitemia of T. congolense infected mice

Rx	D(mg/kg)			Parasitemia level (log number/ml)
		D12	D14	D16	D18	D20	D22	D24	D26
DCM	250	6.96 ± .25	6.66 ± .39^bcd	5.70 ± .37^a	2.16 ± 3.04^bcd	1.08 ± 2.41^bcd	2.16 ± 2.96^bcd	3.24 ± 2.96^a	4.32 ± 2.41
	200	6.66 ± .58	6.48 ± .54^cd	6.12 ± .45^cd	4.5 ± 2.52	3.24 ± 2.98^cd	3.24 ± 2.98^cd	5.52 ± .16	5.88 ± .16
	150	6.66 ± .58	6.72 ± .27^cd	6.54 ± .33^cd	6.12 ± .40	5.88 ± .34	5.70 ± .30	5.94 ± .39	6.06 ± .39
	100	6.90 ± .47	7.14 ± .58	7.32 ± .62	7.32 ± .62	7.20 ± .60	7.86 ± .49	8.22 ± .40	8.46 ± .25
DA	28	7.08 ± .54	.00 ± .00	.00 ± .00	.00 ± .00	.00 ± .00	.00 ± .00	1.08 ± 1.0	2.16 ± 1.32
DMSO	-	7.08 ± .16	7.26 ± .25	7.48 ± .30	7.74 ± .25	7.74 ± .13	8.04 ± .25	8.04 ± .25	8.46 ± .25

Values are Mean ± SD; p < 0.05; N = 5; ^acompared to all but diminazene aceturate; ^bcompared to DCM 150 mg/kg; ^ccompared to DCM 100 mg/kg; ^dcompared to DMSO
Rx Treatment, D Dose, DCM Dichloromethane extract, DA Diminazene aceturate, DMSO Dimethylsulfoxide, D Day, D12 Day of treatment initiation

ISSN: 2662-7671