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Table 2 In vivo anti-trypanosomal activity of dichloromethane crude leaf extract of D. abyssinica on parasitemia of T. congolense infected mice

From: In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense

Rx D(mg/kg)    Parasitemia level (log number/ml)   
   D12 D14 D16 D18 D20 D22 D24 D26
DCM 250 6.96 ± .25 6.66 ± .39bcd 5.70 ± .37a 2.16 ± 3.04bcd 1.08 ± 2.41bcd 2.16 ± 2.96bcd 3.24 ± 2.96a 4.32 ± 2.41
  200 6.66 ± .58 6.48 ± .54cd 6.12 ± .45cd 4.5 ± 2.52 3.24 ± 2.98cd 3.24 ± 2.98cd 5.52 ± .16 5.88 ± .16
  150 6.66 ± .58 6.72 ± .27cd 6.54 ± .33cd 6.12 ± .40 5.88 ± .34 5.70 ± .30 5.94 ± .39 6.06 ± .39
  100 6.90 ± .47 7.14 ± .58 7.32 ± .62 7.32 ± .62 7.20 ± .60 7.86 ± .49 8.22 ± .40 8.46 ± .25
DA 28 7.08 ± .54 .00 ± .00 .00 ± .00 .00 ± .00 .00 ± .00 .00 ± .00 1.08 ± 1.0 2.16 ± 1.32
DMSO - 7.08 ± .16 7.26 ± .25 7.48 ± .30 7.74 ± .25 7.74 ± .13 8.04 ± .25 8.04 ± .25 8.46 ± .25
  1. Values are Mean ± SD; p < 0.05; N = 5; acompared to all but diminazene aceturate; bcompared to DCM 150 mg/kg; ccompared to DCM 100 mg/kg; dcompared to DMSO
  2. Rx Treatment, D Dose, DCM Dichloromethane extract, DA Diminazene aceturate, DMSO Dimethylsulfoxide, D Day, D12 Day of treatment initiation