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Table 5 Micronucleus test in mice following a single oral dose of ORS

From: Genotoxicity evaluation of Oryeong-san water extract using in vitro and in vivo tests

Group Vehicle control ORSE ORSE ORSE Positive control
Dose (mg/kg) 0 500 1000 2000 70
MNPCE/2000PCEs (Mean ± S.D) 0.67 ± 0.58 0.33 ± 0.58 2.00 ± 1.00 1.33 ± 0.58 50.00a ± 13.89
PCE/(PCE + NCE) (Mean ± S.D) 0.60 ± 0.06 0.63 ± 0.04 0.58 ± 0.07 0.55 ± 0.12 0.49a ± 0.03
Number of animals 3 3 3 3 3
  1. MNPCE: PCE with one or more micronuclei; PCE: Polychromatic erythrocyte; NCE: Normochromatic erythrocyte
  2. aSignificantly different from the control at p < 0.05