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Table 1 Zones of inhibition and minimum inhibitory concentrations (MICs) of the latex and compounds isolated from Aloe trigonantha

From: Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach

Microorganism

 

Zones of inhibition in mm (200 μg/mL)

 

MIC (μg/mL)i

Latexii

1ii

2ii

3 ii

4ii

Cipro

Latex

1

2

3

4

Bacillus pumilus 82

6.0 ± 0.0

6.0 ± 0.0a

6.0 ± 0.0a

10.0 ± 0.5b

6.0 ± 0.0a

19.0 ± 1.3

-

-

-

200

-

B. subtilis ATCC 6633

6.0 ± 0.0

6.0 ± 0.0a

6.0 ± 0.0a

10.0 ± 0.6b

6.0 ± 0.0a

18.0 ± 0.7

-

-

-

200

-

Escherichia coli 3:37C

15.0 ± 0.9

15.0 ± 1.2a

15.0 ± 0.9a

14.5 ± 0.5a

15.0 ± 0.7a

16.5 ± 0.8

50

25

25

10

25

E. coli 872

15.0 ± 0.7

14.5 ± 0.9a

14.5 ± 0.6a

14.5 ± 0.4a

14.5 ± 1.2a

16.0 ± 0.9

50

25

25

10

25

E. coli CD/99/1

15.0 ± 0.8

15.0 ± 0.7a

15.0 ± 0.8a

15.5 ± 0.9a

15.0 ± 0.9a

17.0 ± 1.4

50

25

25

10

25

E. coli K88

16.5 ± 1.1

15.5 ± 0.5b

15.5 ± 1.2b

15.0 ± 1.0b

15.5 ± 0.9b

17.0 ± 0.5

50

50

25

10

25

E. coli LT37

15.5 ± 0.6

14.5 ± 0.4b

14.5 ± 1.1b

14.5 ± 1.0b

14.5 ± 0.5b

16.0 ± 0.8

50

25

25

10

25

E. coli NCTC 5933

15.5 ± 1.2

15.0 ± 0.9a

14.5 ± 0.9b

14.5 ± 0.5b

15.0 ± 0.8a

16.0 ± 0.6

50

50

50

10

25

E. coli NCTC 7360

16.5 ± 1.0

15.5 ± 1.1b

14.5 ± 0.6b

14.5 ± 0.7b

15.5 ± 0.7b

17.0 ± 1.3

50

50

50

10

25

E. coli ROW 7/12

15.5 ± 0.7

15.0 ± 0.9a

15.0 ± 0.5a

14.5 ± 0.2a

15.0 ± 0.6a

16.5 ± 0.4

50

25

25

10

25

Salmonella enterica TD 01

16.5 ± 0.9

15.0 ± 0.6b

13.5 ± 0.8b

12.5 ± 0.5b

16.0 ± 1.2a

19.0 ± 0.9

50

50

100

50

25

S. typhi Ty2

15.0 ± 1.2

15.0 ± 0.8a

14.0 ± 0.7b

14.0 ± 0.6b

15.0 ± 0.9a

16.0 ± 0.5

50

25

50

10

25

Shigella boydii D 13629

15.0 ± 0.5

15.5 ± 0.8a

14.5 ± 0.9a

16.5 ± 0.4a

15.5 ± 0.6a

20.0 ± 0.7

50

50

50

10

50

S. dysentery 8

14.5 ± 0.8

14.0 ± 0.7a

13.5 ± 0.9b

15.5 ± 0.6b

13.5 ± 0.4b

20.0 ± 0.8

50

25

50

10

50

S. flexneri Type 6

15.0 ± 0.7

15.5 ± 0.5a

15.5 ± 0.6a

15.5 ± 0.5a

15.5 ± 0.7a

20.5 ± 0.7

50

50

50

10

50

S. soneii 1

15.0 ± 0.5

15.5 ± 0.9a

15.5 ± 0.8a

15.5 ± 0.5a

15.5 ± 0.6a

19.5 ± 1.2

50

100

50

10

50

Staphylococcus aureus ML 267

14.5 ± 0.9

14.5 ± 1.3a

14.5 ± 0.5a

14.5 ± 0.6a

13.5 ± 0.9b

18.0 ± 1.4

100

50

100

25

100

Vibrio cholerae NCTC 10732

14.0 ± 0.4

15.5 ± 0.8b

15.0 ± 1.1b

14.5 ± 1.0b

15.5 ± 0.9b

19.0 ± 0.9

50

25

25

10

25

V. cholerae NCTC 11501

14.5 ± 0.6

15.5 ± 0.4b

14.0 ± 0.7a

15.0 ± 0.3a

15.5 ± 0.7b

18.5 ± 0.8

50

25

25

10

25

V. cholerae NCTC 4693

13.5 ± 0.8

14.5 ± 0.9b

15.0 ± 0.8b

15.0 ± 0.3b

14.5 ± 0.9b

17.5 ± 0.5

50

25

25

10

25

V. cholerae NCTC 5596

14.0 ± 0.3

15.0 ± 0.7b

15.0 ± 0.7b

15.0 ± 0.5b

15.0 ± 0.5b

18.5 ± 0.8

50

25

25

10

25

Fungal strains

Latexii

1ii

2ii

3ii

4ii

Gris.

Latex

1

2

3

4

Aspergillus niger ATCC 6275

9.0 ± 0.7

11.0 ± 1.3b

12.0 ± 0.9b

12.5 ± 0.6b

12.5 ± 0.9b

15.0 ± 0.9

1500

1000

1000

800

1000

Candida albicans ATCC 10231

10.0 ± 0.9

10.0 ± 0.8a

14.0 ± 1.2b

13.5 ± 1.0b

14.5 ± 0.8b

16.0 ± 1.3

800

400

400

800

400

Penicillium funiculosum NCTC 287

8.0 ± 0.6

9.5 ± 0.5a

12.5 ± 0.7b

12.0 ± 0.4b

13.5 ± 0.5b

13.5 ± 1.1

1000

800

800

800

400

P. notatum ATCC 11625

8.0 ± 0.8

10.0 ± 0.7b

12.5 ± 0.6b

12.0 ± 0.5b

12.5 ± 0.4b

13.5 ± 0.9

1000

800

800

800

400

  1. iMIC expressed as an average from three independent experiments, each performed in triplicate; iiZones of inhibitions were expressed as means ± SEM including the 6 mm diameter of the disc; a: p > 0.05 when compared to the latex on the same row; b: p < 0.05 when compared to the latex on the same row; 1: Aloesin, 2: 8-O-Methyl-7-hydroxyaloin A/B, 3: Aloin A/B; 4: Aloin-6’-O-acetate A/B; Cipro: Ciprofloxacin; Gris: Griseofulvin