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Table 1 Zones of inhibition and minimum inhibitory concentrations (MICs) of the latex and compounds isolated from Aloe trigonantha

From: Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach

Microorganism   Zones of inhibition in mm (200 μg/mL)   MIC (μg/mL)i
Latexii 1ii 2ii 3 ii 4ii Cipro Latex 1 2 3 4
Bacillus pumilus 82 6.0 ± 0.0 6.0 ± 0.0a 6.0 ± 0.0a 10.0 ± 0.5b 6.0 ± 0.0a 19.0 ± 1.3 - - - 200 -
B. subtilis ATCC 6633 6.0 ± 0.0 6.0 ± 0.0a 6.0 ± 0.0a 10.0 ± 0.6b 6.0 ± 0.0a 18.0 ± 0.7 - - - 200 -
Escherichia coli 3:37C 15.0 ± 0.9 15.0 ± 1.2a 15.0 ± 0.9a 14.5 ± 0.5a 15.0 ± 0.7a 16.5 ± 0.8 50 25 25 10 25
E. coli 872 15.0 ± 0.7 14.5 ± 0.9a 14.5 ± 0.6a 14.5 ± 0.4a 14.5 ± 1.2a 16.0 ± 0.9 50 25 25 10 25
E. coli CD/99/1 15.0 ± 0.8 15.0 ± 0.7a 15.0 ± 0.8a 15.5 ± 0.9a 15.0 ± 0.9a 17.0 ± 1.4 50 25 25 10 25
E. coli K88 16.5 ± 1.1 15.5 ± 0.5b 15.5 ± 1.2b 15.0 ± 1.0b 15.5 ± 0.9b 17.0 ± 0.5 50 50 25 10 25
E. coli LT37 15.5 ± 0.6 14.5 ± 0.4b 14.5 ± 1.1b 14.5 ± 1.0b 14.5 ± 0.5b 16.0 ± 0.8 50 25 25 10 25
E. coli NCTC 5933 15.5 ± 1.2 15.0 ± 0.9a 14.5 ± 0.9b 14.5 ± 0.5b 15.0 ± 0.8a 16.0 ± 0.6 50 50 50 10 25
E. coli NCTC 7360 16.5 ± 1.0 15.5 ± 1.1b 14.5 ± 0.6b 14.5 ± 0.7b 15.5 ± 0.7b 17.0 ± 1.3 50 50 50 10 25
E. coli ROW 7/12 15.5 ± 0.7 15.0 ± 0.9a 15.0 ± 0.5a 14.5 ± 0.2a 15.0 ± 0.6a 16.5 ± 0.4 50 25 25 10 25
Salmonella enterica TD 01 16.5 ± 0.9 15.0 ± 0.6b 13.5 ± 0.8b 12.5 ± 0.5b 16.0 ± 1.2a 19.0 ± 0.9 50 50 100 50 25
S. typhi Ty2 15.0 ± 1.2 15.0 ± 0.8a 14.0 ± 0.7b 14.0 ± 0.6b 15.0 ± 0.9a 16.0 ± 0.5 50 25 50 10 25
Shigella boydii D 13629 15.0 ± 0.5 15.5 ± 0.8a 14.5 ± 0.9a 16.5 ± 0.4a 15.5 ± 0.6a 20.0 ± 0.7 50 50 50 10 50
S. dysentery 8 14.5 ± 0.8 14.0 ± 0.7a 13.5 ± 0.9b 15.5 ± 0.6b 13.5 ± 0.4b 20.0 ± 0.8 50 25 50 10 50
S. flexneri Type 6 15.0 ± 0.7 15.5 ± 0.5a 15.5 ± 0.6a 15.5 ± 0.5a 15.5 ± 0.7a 20.5 ± 0.7 50 50 50 10 50
S. soneii 1 15.0 ± 0.5 15.5 ± 0.9a 15.5 ± 0.8a 15.5 ± 0.5a 15.5 ± 0.6a 19.5 ± 1.2 50 100 50 10 50
Staphylococcus aureus ML 267 14.5 ± 0.9 14.5 ± 1.3a 14.5 ± 0.5a 14.5 ± 0.6a 13.5 ± 0.9b 18.0 ± 1.4 100 50 100 25 100
Vibrio cholerae NCTC 10732 14.0 ± 0.4 15.5 ± 0.8b 15.0 ± 1.1b 14.5 ± 1.0b 15.5 ± 0.9b 19.0 ± 0.9 50 25 25 10 25
V. cholerae NCTC 11501 14.5 ± 0.6 15.5 ± 0.4b 14.0 ± 0.7a 15.0 ± 0.3a 15.5 ± 0.7b 18.5 ± 0.8 50 25 25 10 25
V. cholerae NCTC 4693 13.5 ± 0.8 14.5 ± 0.9b 15.0 ± 0.8b 15.0 ± 0.3b 14.5 ± 0.9b 17.5 ± 0.5 50 25 25 10 25
V. cholerae NCTC 5596 14.0 ± 0.3 15.0 ± 0.7b 15.0 ± 0.7b 15.0 ± 0.5b 15.0 ± 0.5b 18.5 ± 0.8 50 25 25 10 25
Fungal strains Latexii 1ii 2ii 3ii 4ii Gris. Latex 1 2 3 4
Aspergillus niger ATCC 6275 9.0 ± 0.7 11.0 ± 1.3b 12.0 ± 0.9b 12.5 ± 0.6b 12.5 ± 0.9b 15.0 ± 0.9 1500 1000 1000 800 1000
Candida albicans ATCC 10231 10.0 ± 0.9 10.0 ± 0.8a 14.0 ± 1.2b 13.5 ± 1.0b 14.5 ± 0.8b 16.0 ± 1.3 800 400 400 800 400
Penicillium funiculosum NCTC 287 8.0 ± 0.6 9.5 ± 0.5a 12.5 ± 0.7b 12.0 ± 0.4b 13.5 ± 0.5b 13.5 ± 1.1 1000 800 800 800 400
P. notatum ATCC 11625 8.0 ± 0.8 10.0 ± 0.7b 12.5 ± 0.6b 12.0 ± 0.5b 12.5 ± 0.4b 13.5 ± 0.9 1000 800 800 800 400
  1. iMIC expressed as an average from three independent experiments, each performed in triplicate; iiZones of inhibitions were expressed as means ± SEM including the 6 mm diameter of the disc; a: p > 0.05 when compared to the latex on the same row; b: p < 0.05 when compared to the latex on the same row; 1: Aloesin, 2: 8-O-Methyl-7-hydroxyaloin A/B, 3: Aloin A/B; 4: Aloin-6’-O-acetate A/B; Cipro: Ciprofloxacin; Gris: Griseofulvin