Fig. 4

Real-time PCR analysis of HIF-1α, SDF-1, CXCR4 and VEGF mRNA levels in OIR mice. When compared with normal controls, the relative expression levels of the HIF-1α (a), SDF-1 (b), CXCR4 (c) and VEGF (d) mRNAs were markedly increased in the retinas of OIR mice and dramatically reduced after SMT treatment. Con, normal control mice; OIR, saline-treated OIR mice; SMT-10, OIR mice treated with SMT (10 mg/kg); and SMT-50, OIR mice treated with SMT (50 mg/kg). The data are shown as the mean ± SE (n = 4; #\( p \) < 0.05, ##\( p \) < 0.0001 vs. the normal control mice, *p < 0.05 vs. saline-treated OIR mice)