Fig. 3

Expression of retinal angiogenesis-related proteins in OIR mice. (a) Proteins whose expression was modulated in retinas treated with SMT are indicated by numbers. Con, normal control mice; OIR, saline-treated OIR mice; SMT-10, OIR mice treated with 10 mg/kg of SMT; and SMT-50, OIR mice treated with 50 mg/kg SMT. 1: Endostatin; 2: IGFBP-2, insulin-like growth factor binding protein 2; 3: CXCL4; 4: SDF-1, stromal cell-derived factor 1; 5: Serpin E1. (b) The levels of pro- and anti-angiogenic factors in the retina were analyzed using protein arrays and quantified using ImageJ software. The positive controls are located in three corners of the arrays, and the negative control is located in the lower right corner of the arrays