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Table 2 Mean pharmacokinetic parameters in tissues after treatment with CDDP (18 mg/kg) alone or in combination with ZMYL (2 g/kg)

From: Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice

Pharmacokinetic parameters CDDP CDDP + ZMYL
Liver Kidney Spleen Tumor Liver Kidney Spleen Tumor
AUC(0~48) (μg · h/mL) 276.7 373.3 135.9 79.2 279.5 359.4 129.6 78.6
MRT (h) 525.7 176.9 6165.3 351.6 594.6 209.5 294.4 146.6
Vd (L/kg) 3074.4 2059.0 6333.5 10704.4 3164.8 2232.1 6121.4 9492.2
CL (mL/h/kg) 5.832 11.577 1.027 30.229 5.293 10.55 20.806 64.65
T1/2e (h) 365.331 123.252 4272.58 245.402 414.337 146.622 203.886 101.75
Ke (1/h) 0.002 0.006 0 0.003 0.002 0.005 0.003 0.007