Pharmacokinetic parameters | CDDP | CDDP + ZMYL | ||||||
---|---|---|---|---|---|---|---|---|
Liver | Kidney | Spleen | Tumor | Liver | Kidney | Spleen | Tumor | |
AUC(0~48) (μg · h/mL) | 276.7 | 373.3 | 135.9 | 79.2 | 279.5 | 359.4 | 129.6 | 78.6 |
MRT (h) | 525.7 | 176.9 | 6165.3 | 351.6 | 594.6 | 209.5 | 294.4 | 146.6 |
Vd (L/kg) | 3074.4 | 2059.0 | 6333.5 | 10704.4 | 3164.8 | 2232.1 | 6121.4 | 9492.2 |
CL (mL/h/kg) | 5.832 | 11.577 | 1.027 | 30.229 | 5.293 | 10.55 | 20.806 | 64.65 |
T1/2e (h) | 365.331 | 123.252 | 4272.58 | 245.402 | 414.337 | 146.622 | 203.886 | 101.75 |
Ke (1/h) | 0.002 | 0.006 | 0 | 0.003 | 0.002 | 0.005 | 0.003 | 0.007 |