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Table 2 Mean pharmacokinetic parameters in tissues after treatment with CDDP (18 mg/kg) alone or in combination with ZMYL (2 g/kg)

From: Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice

Pharmacokinetic parameters

CDDP

CDDP + ZMYL

Liver

Kidney

Spleen

Tumor

Liver

Kidney

Spleen

Tumor

AUC(0~48) (μg · h/mL)

276.7

373.3

135.9

79.2

279.5

359.4

129.6

78.6

MRT (h)

525.7

176.9

6165.3

351.6

594.6

209.5

294.4

146.6

Vd (L/kg)

3074.4

2059.0

6333.5

10704.4

3164.8

2232.1

6121.4

9492.2

CL (mL/h/kg)

5.832

11.577

1.027

30.229

5.293

10.55

20.806

64.65

T1/2e (h)

365.331

123.252

4272.58

245.402

414.337

146.622

203.886

101.75

Ke (1/h)

0.002

0.006

0

0.003

0.002

0.005

0.003

0.007