Table 1 Mean pharmacokinetic parameters of platinum originating from CDDP in plasma and plasma ultra-filtrate after intraperitoneally administration of CDDP at dose of 18 mg/kg and co-administration with ZMYL at dose of 2 g/kg (mean ± SD, n = 6)
Pharmacokinetic parameters | CDDP | CDDP + ZMYL | ||
|---|---|---|---|---|
Free pt | Total pt | Free pt | Total pt | |
AUC(0~48) (μg · h/mL) | 1.5 | 44.6 | 1.6 | 46.6 |
MRT (h) | 1857.4 | 61.6 | 409.1 | 57.3 |
Vd (L/kg) | 671.018 | 15.2 | 593.758 | 14.883 |
CL (mL/h/kg) | 358.891 | 223.575 | 1417.647 | 225.295 |
T1/2e (h) | 1295.703 | 47.117 | 290.252 | 45.778 |
Ke (1/h) | 0.001 | 0.015 | 0.002 | 0.015 |