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Table 1 Mean pharmacokinetic parameters of platinum originating from CDDP in plasma and plasma ultra-filtrate after intraperitoneally administration of CDDP at dose of 18 mg/kg and co-administration with ZMYL at dose of 2 g/kg (mean ± SD, n = 6)

From: Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice

Pharmacokinetic parameters CDDP CDDP + ZMYL
Free pt Total pt Free pt Total pt
AUC(0~48) (μg · h/mL) 1.5 44.6 1.6 46.6
MRT (h) 1857.4 61.6 409.1 57.3
Vd (L/kg) 671.018 15.2 593.758 14.883
CL (mL/h/kg) 358.891 223.575 1417.647 225.295
T1/2e (h) 1295.703 47.117 290.252 45.778
Ke (1/h) 0.001 0.015 0.002 0.015