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Table 8 In vivo assessment of the antioxidant activity of S.nigra aqueous extract (Elder), Kaempferol (KMF) using catalase levels in serum of alloxan-induced diabetic mice (n = 7)

From: Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Group

Dose (mg/kg)

Catalase level ± S.E.M. (kU/I)

  

1st day

3rd day

5th day

8th day

Control

__

41.00 ± 1.50

41.50 ± 1.60

40.86 ± 1.20

41.62 ± 1.70

Diabetic controla

__

23.67 ± 1.60***

24.93 ± 1.30***

23.01 ± 1.90***

22.02 ± 1.40***

GBb

5

22.60 ± 1.70

25.00 ± 1.70

31.54 ± 1.40*

32.37 ± 1.00**

Elderb

50

26.81 ± 1.40

25.98 ± 3.10

26.50 ± 2.50

27.60 ± 1.60*

Elderb

100

25.77 ± 1.70

24.25 ± 2.10

25.70 ± 2.30

26.80 ± 1.20*

Elderb

200

26.22 ± 1.60

26.67 ± 2.30

27.80 ± 2.60

28.70 ± 1.30*

KMFb

16

24.22 ± 0.60

23.94 ± 0.30

26.00 ± 1.00

28.74 ± 1.10*

KMFb

32

22.33 ± 1.10

23.41 ± 1.20

25.91 ± 1.40

28.23 ± 1.20*

KMFb

64

24.20 ± 0.70

25.55 ± 0.90

30.05 ± 0.70

31.32 ± 1.30*

  1. S.E.M. standard error of the mean
  2. *p < 0.05 significant from the control animals
  3. **p < 0.01 significant from the control animals
  4. ***p < 0.001 significant from the control animals
  5. aCompared to vehicle control
  6. bCompared to diabetic control