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Table 3 Subchronic effect of F.hermonis EtAc extract (Ferula), Ferutinin (Ft) on blood glucose of alloxan-induced diabetic mice (n = 7)

From: Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Group

Dose (mg/kg)

Mean blood glucose concentration ± S.E.M. (mg/dL)

 
  

1st day

3rd day

5th day

8th day

Control

__

107.90 ± 2.50

109.80 ± 3.60

108.56 ± 3.20

109.50 ± 3.70

Diabetic controla

__

207.79 ± 5.60***

214.93 ± 4.50***

209.91 ± 9.70***

210.55 ± 7.30***

GBb

5

186.70 ± 3.70

179.53 ± 2.90

161.54 ± 2.40**

171.97 ± 3.10

Ferula

12.5

162.67 ± 2.60

152.33 ± 3.10

142.69 ± 2.02

132.53 ± 3.60*

Ferula

25

143.34 ± 1.90

134.88 ± 3.10

134.48 ± 2.60

127.55 ± 2.40*

Ferula

50

142.12 ± 1.30

138.56 ± 2.80

112.66 ± 1.90

111.42 ± 1.60*

Ft

0.4

144.11 ± 1.20

134.89 ± 3.10

155.32 ± 2.50

136.13 ± 1.30*

Ft

0.8

120.33 ± 1.70

148.52 ± 2.70

140.44 ± 2.70

132.33 ± 1.50*

Ft

1.6

125.21 ± 2.90

142.56 ± 2.10

137.89 ± 2.60

122.13 ± 1.60*

  1. S.E.M. standard error of the mean
  2. *p < 0.05 significant from the control animals
  3. **p < 0.01 significant from the control animals
  4. ***p < 0.001 significant from the control animals
  5. aCompared to vehicle control
  6. bCompared to diabetic control