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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Fig. 4

Effect of Ferutinin (Ft) and Tramadol (TRA) 10 mg/kg, as positive control, on the hot plate and tail withdrawal latencies in alloxan-induced diabetic mice. a Hot plate latency: (Crossed-triangles, straight line) NORM: normal control mice. (Closed-squares, straight-line) DIA + VEH: diabetic animals treated with vehicle as control. (Solid-stars, dotted-line) Positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg. (Solid-circles, straight-line) DIA + Ft 0.4 mg/kg: diabetic animals treated with Ft 0.4 mg/kg. (Up-triangles, dashed-line) DIA + Ft 0.8 mg/kg: diabetic animals treated with Ft 0.8 mg/kg. (Right-triangles, dashed-dotted-line) DIA + Ft 1.6 mg/kg: diabetic animals treated with Ft 1.6 mg/kg. b Tail withdrawal latency: (Crossed-triangles, straight line) NORM: normal control mice. (Closed-squares, straight-line) DIA + VEH: diabetic animals treated with vehicle as control. (Solid-stars, dotted-line) Positive control TRA 10 mg/kg: alloxan treated mice with TRA 10 mg/kg. (Solid-circles, straight-line) DIA + Ft 0.4 mg/kg: diabetic animals treated with Ft 0.4 mg/kg. (Up-triangles, dashed-line) DIA + Ft 0.8 mg/kg: diabetic animals treated with Ft 0.8 mg/kg. (Right-triangles, dashed-dotted-line) DIA + Ft 1.6 mg/kg: diabetic animals treated with Ft 1.6 mg/kg. Data are expressed in mean ± S.E.M. “*” means P < 0 .05 compared with vehicle. “**” means P < 0 .01 compared with vehicle

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