Table 2 Factorial analysis [2 × 2 factorial design (untreated/treated, treatment for 7/28 d)] of IL-6, IL-17, IL-23, TGF-β levels and RORγt, Foxp3 expression between the MDL and DEX groups
From: Pingchuan formula improves asthma via restoration of the Th17/Treg balance in a mouse model
Variation | Indicator | SS | df | MS | F | P |
|---|---|---|---|---|---|---|
Group (difference between MDL and DEX group) | IL-6 | 56480.11 | 1 | 56480.11 | 346.92 | <0.001 |
IL-17 | 10396.43 | 1 | 10396.43 | 118.14 | <0.001 | |
IL-23 | 168584.56 | 1 | 168584.56 | 329.16 | <0.001 | |
TGF-β | 197694.57 | 1 | 197694.57 | 88.65 | <0.001 | |
RORγt | 0.45 | 1 | 0.45 | 27.11 | <0.001 | |
Foxp3 | 0.52 | 1 | 0.52 | 66.39 | <0.001 | |
Time (difference between 7 d and 28 d treatment) | IL-6 | 0.11 | 1 | 0.11 | 0.00 | 0.979 |
IL-17 | 1169.06 | 1 | 1169.06 | 13.29 | 0.001 | |
IL-23 | 4214.55 | 1 | 4214.55 | 8.23 | 0.007 | |
TGF-β | 21824.31 | 1 | 21824.31 | 9.79 | 0.003 | |
RORγt | 0.04 | 1 | 0.04 | 2.26 | 0.141 | |
Foxp3 | 0.01 | 1 | 0.01 | 1.36 | 0.251 | |
Group *Time | IL-6 | 220.59 | 1 | 220.59 | 1.36 | 0.252 |
IL-17 | 0.20 | 1 | 0.20 | 0.00 | 0.962 | |
IL-23 | 4784.55 | 1 | 4784.55 | 9.34 | 0.004 | |
TGF-β | 25241.88 | 1 | 25241.88 | 11.32 | 0.002 | |
RORγt | 0.01 | 1 | 0.01 | 0.49 | 0.490 | |
Foxp3 | 0.00 | 1 | 0.00 | 0.04 | 0.841 | |
SE | IL-6 | 5860.97 | 36 | 162.81 | -- | -- |
IL-17 | 3167.92 | 36 | 88.00 | -- | -- | |
IL-23 | 18438.26 | 36 | 512.17 | -- | -- | |
TGF-β | 80284.78 | 36 | 2230.13 | -- | -- | |
RORγt | 0.59 | 36 | 0.02 | -- | -- | |
Foxp3 | 0.28 | 36 | 0.01 | -- | -- |