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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat

Fig. 3

Hematoxylin and eosin-stained sections of rat liver: a and b Shows the general morphology of the classic liver (hepatic) lobule. It is roughly hexagonal in shape. At the center of the lobule is the central vein (CV). The hepatocytes (H) are organized into anastomosing cords or plates, one cell thick, separated by anastomosing hepatic sinusoids (S).; c and d Mulberry treated rat showed normal structure of heptic tissue. e and f Methotrexate (20 mg/kg) treated rat; e shows focal area of necrosis (head arrow) around the central vein where the cell boundaries were lost. f Shows heavy cell infiltration associated with fibrosis around the portal tract (arrow) and cloudy swelling of hepatocytes (CW). g and h Liver section from rats pre-treated with 500 mg/kg mulberry leaf extract and challenged with MTX showed preserved periventricular (cv) structure, absence of fibrosis, while noticing mild hydropic degeneration (HD) of hepatocytes. Bar = 100 μm. Bars represent mean ± SEM of histopathological scoring of the effect of mulberry leaf extracts on induced MTX-hepatic toxicity. a indicates significantly different values when comparing control animals, p < 0.05. b indicates significantly different values when comparing to MTX-group, p < 0.05

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