Fig. 7

Protective effects of PMC-12 on expression of both pCREB and mature BDNF in the hippocampus of focal cerebral ischemia in mice at 26 days after MCAO. Photomicrograph (a-b, d-e) and its histogram for pCREB/NeuN (c) and mature BDNF/NeuN double-positive cells (f) in the DG and CA1 regions of the hippocampus. Total number of pCREB/NeuN and mBDNF/NeuN double-positive cells was significantly increased by administration of PMC-12 in DG and CA1 compared to the MCAO group. ^##P < 0.01 and ^###P < 0.001 vs. control^; *P < 0.05 and **P < 0.01 vs. MCAO mice. Scale bar = 100 μm