Fig. 1

Dose-dependent effect of Haelan on the viability of pancreatic carcinoma cells and fibroblasts. CAPAN-1 cells (a), BxPC-3 cells (b), AR42J cells (c) and fibroblasts (d) were incubated with or without increasing concentrations of Haelan. After 24 h, cellular viability was assessed using the LDH cytotoxicity assay. Haelan concentrations of 2 %-8 % induce no cytotoxic effects, whereas concentrations higher than 8 % cause significant plasma membrane damage in all cell lines investigated. The results are expressed as mean + SEM (n = 3-12). ⁺P < 0.1, *P < 0.05, **P < 0.01, control vs. Haelan-treated cells