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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways

Fig. 1

Effects of Xia-yu-xue decoction (XYXD) on histological changes in CCl4-induced liver fibrosis in mice. a HE staining (×100), (b) Sirius red staining (×100). CCl4 (10 %, 2 mg/kg of body weight) was administered intraperitoneally to CCl4-treatment mice for tri-weekly and distilled water (by gavage) daily for 6 weeks. The normal mice received an equal amount of corn oil and distilled water (by gavage) daily for 6 weeks. At the end of the third week, 10 CCl4-treated mice were for the fibrosis development assessment. The XYXD treatment group was exposed to the same level of CCl4 and administered XYXD at a dose of 0.467 g/100 g body weight, which is equivalent to human dose in clinical therapeutics daily for 6 weeks until sacrifice. The number in HE and Sirius red staining was as the same as the animal number in each group

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