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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish)

Fig. 2

PTZ concentration-response. The latency to Stage 7 PTZ-evoked convulsions was determined in adult zebrafish. Naïve zebrafish (n = 6–12) were placed in the convulsion chamber containing PTZ (0.5–20 mg/ml; 0.7–145 mM). The seizure latency period was defined as the time from initial exposure to PTZ until the beginning of Stage 7 (wild jumping immediately followed by loss of posture). The EC50 for PTZ-evoked convulsions was 0.49 mg/ml (95 % Confidence Interval, 0.43 to 0.56 mg/ml). Data are mean ± SEM

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