Fig. 4
From: Chansu inhibits the expression of cortactin in colon cancer cell lines in vitro and in vivo
CBF inhibited cortactin synthesis in xenografts. a A nude mouse model bearing HCT116 tumour. The mouse was sacrificed when the tumour size reached 1 cm3. b Tumour size vs days of treatment (N = 7). Compared with the control, the i.p. group showed a slight suppression of tumour growth after the drug injection. c Analysis of cortactin mRNA level in tumour tissues. A significant decrease of cortactin mRNA level presented in i.p. group. Results are means with standard errors from four replicates. The level of GAPDH as a control was set to 1.0. d Abundant cortactin protein expression only in the control group. The i.p. group showed diminished expression of cortactin. The absence of cortactin in lane 6 of control group was an exemption with an unknown reason