Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice

Table 3 Chemosuppressive effect of crude aqueous, chloroform and methanol leaf extracts of O. quadripartita in P. berghei-infected mice

Description	Dose (mg/kg/day)	% parasitaemia	p-value	% suppression	MST ± SEM	p-value
Aqueous	200	63.02 ± 3.91	0.740	0.37	6.2 ± 0.37	0.418
	400	54.62 ± 2.20	0.142	16.53	7.4 ± 0.51*	0.018
	600	51.26 ± 2.05	0.056	21.67	8.2 ± 0.37*	0.001
Methanol	200	55.92 ± 0.84	0.196	14.5	7.4 ± 0.51*	0.018
	400	50.94 ± 1.24	0.510	22.16	8.2 ± 0.37*	0.001
	600	49.48 ± 2.06*	0.033	24.4	8.4 ± 0.24*	0.000
Chloroform	200	44.48 ± 10.18*	0.006	31.7	8.0 ± 1.14*	0.004
	400	40.7 ± 9.66*	0.001	37.5	9.8 ± 0.58*	0.000
	600	38.26 ± 8.78*	0.001	41.26	11 ± 0.63*	0.000
DH₂O (NC)	0.2 ml	65.44 ± 1.7	-	0.00	5.6 ± 0.24
T-80 (NC)	0.2 ml	65.14 ± 1.7	-	0.00	5.8 ± 0.37
CQ	25	0.00	0.000	100	ND

Keys: mg/kg/day: 1 mg of extract per one kilogram of mice for one day; MST: mean survival time; SEM: standard error of the mean; NC: negative control; T-80 = Tween-80 (NC for chloroform extract); dH₂O: distilled water (NC for aqueous and methanol extract); CQ: chloroquine phosphate; ND: no death *: significant compared with that of NC

ISSN: 2662-7671