Fig. 5From: L-Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate-1Schematic overview showing the beneficial effects of L-Cit on improved insulin resistance associated with enhanced insulin sensitivity through the activation of IRS1 followed by the inhibition of serine 1101 phosphorylation. Arrows indicate positive inputs (activation), whereas perpendicular lines show negative inputs (inhibition)Back to article page