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Table 5 Antinociceptive effect of the constituent plant extracts of Nefang on heat-induced nociceptive pain in mice

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract) Dose (mg/kg) Mice reaction time [RT] (sec) and pain inhibition [PI] (%) at designated time intervals (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)
   0 min   30 min   60 min   120 min  
   RT PI RT PI RT PI RT PI
Normal Saline - 9.51 ± 1.24 0 10.70 ± 1.07 12.6 10.56 ± 0.74 11.0 11.28 ± 0.67 18.6
Piroxicam 20 10.29 ± 0.61 0 19.31 ± 1.34* 87.7 47.49 ± 0.76** 361.6 47.41 ± 0.66** 360.8
Pethidine 50 9.44 ± 0.17 0 18.90 ± 0.92* 100.2 19.15 ± 0.77* 102.8 20.02 ± 1.14* 112.0
Mangifera indica bark 300 9.93 ± 0.25 0 13.90 ± 1.21 40.0 21.75 ± 1.28* 119.0 20.81 ± 0.68* 109.6
600 9.63 ± 0.69 0 13.65 ± 0.34 41.8 22.23 ± 0.71* 131.0 22.61 ± 0.70* 134.8
1200 10.05 ± 0.26 0 22.91 ± 0.89* 128.0 27.29 ± 0.62* 171.7 23.79 ± 1.81* 136.8
Mangifera indica leaf 300 11.11 ± 0.94 0 12.80 ± 0.58 15.2 16.71 ± 0.50* 50.4 16.11 ± 0.26 45.0
  600 11.21 ± 0.48 0 23.72 ± 0.88* 111.6 24.25 ± 1.17* 116.3 21.71 ± 0.68* 93.7
  1200 10.70 ± 0.53 0 23.41 ± 1.07* 118.8 32.75 ± 0.25** 206.1 28.56 ± 0.13* 167.0
Psidium guajava leaf 300 10.09 ± 0.45 0 14.41 ± 0.73 42.8 14.57 ± 0.68 44.4 13.79 ± 1.14 36.6
600 9.84 ± 0.34 0 14.86 ± 0.51 51.1 15.47 ± 0.21 57.3 18.33 ± 0.29 86.3
1200 10.29 ± 0.53 0 21.27 ± 0.46* 106.7 26.29 ± 0.24* 155.4 24.22 ± 0.57* 135.3
Carica papaya leaf 300 9.63 ± 0.48 0 11.46 ± 0.94 19.0 11.51 ± 0.36 19.5 10.79 ± 0.61 12.0
600 9.45 ± 0.40 0 12.28 ± 0.84 30.0 12.51 ± 0.38 32.5 11.01 ± 0.72 16.6
1200 9.90 ± 0.77 0 12.45 ± 0.28 25.8 17.42 ± 0.25* 76.0 16.91 ± 0.62 70.8
Cymbopogon citratus leaf 300 10.07 ± 0.34 0 11.00 ± 0.36 9.2 11.71 ± 0.38 16.3 15.28 ± 0.56 51.7
600 9.78 ± 0.34 0 13.34 ± 0.77 36.4 13.02 ± 0.45 33.1 16.08 ± 0.72 64.4
1200 10.05 ± 0.33 0 15.24 ± 1.12 51.6 14.81 ± 1.10 47.3 18.85 ± 0.57 75.0
Citrus sinensis leaf 300 9.90 ± 0.44 0 13.24 ± 0.60 33.7 12.83 ± 0.24 29.6 13.27 ± 0.70 34.1
600 9.86 ± 0.46 0 15.10 ± 0.61 53.2 14.99 ± 0.90 52.1 13.60 ± 0.43 38.0±
1200 9.73 ± 0.33 0 14.21 ± 0.67 46.0 16.34 ± 0.60* 67.9 15.03 ± 1.37 54.5
Ocimum gratissimum leaf 300 9.63 ± 0.36 0 13.66 ± 0.30 41.8 18.15 ± 0.89* 88.5 18.98 ± 0.92 97.0
  600 9.79 ± 0.28 0 13.66 ± 0.89 39.5 22.83 ± 0.20* 133.2 24.29 ± 1.17* 148.1
  1200 10.07 ± 0.70 0 28.98 ± 0.64* 187.7 29.94 ± 0.43** 197.2 32.55 ± 1.47** 223.1
  1. Significant difference * - p < 0.05; ** - p < 0.001 when compared to the control