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Table 3 Anti-inflammatory effect of the constituent plant extracts of Nefang on carrangeenan-induced paw edema in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract)

Dose (mg/kg)

Increase in paw volumes [PV] (mL) and edema inhibition [EI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=5\right) \)

  

0

60

 

120

 

180

 

240

 
   

PV

EI

PV

EI

PV

EI

PV

EI

Normal Saline

-

0

1.18 ± 0.08

0.0

1.28 ± 0.14

0.0

1.46 ± 0.13

0.0

1.56 ± 0.09

0.0

Indomethacin

10

0

1.17 ± 0.04

1.3

1.08 ± 0.03*

15.3

1.00 ± 0.10**

31.5

0.88 ± 0.03**

43.7

Mangifera indica bark

100

0

1.07 ± 0.11

9.7

1.13 ± 0.09*

11.4

1.19 ± 0.03*

18.8

1.12 ± 0.01**

28.3

200

0

1.15 ± 0.12

3.0

1.21 ± 0.02

5.5

1.32 ± 0.06*

9.9

1.24 ± 0.10*

20.6

400

0

1.18 ± 0.05

0.4

1.27 ± 0.04

0.8

1.36 ± 0.03

6.8

1.26 ± 0.06*

19.0

Mangifera indica leaf

100

0

1.04 ± 0.13

11.9

1.01 ± 0.08*

20.8

0.92 ± 0.08**

37.3

0.93 ± 0.06**

40.2

200

0

1.05 ± 0.03

11.4

1.11 ± 0.08*

13.3

0.91 ± 0.14**

37.7

0.95 ± 0.11**

39.2

400

0

1.05 ± 0.03

11.4

0.93 ± 0.03*

27.5

0.89 ± 0.06**

39.4

0.88 ± 0.08**

43.4

Psidium guajava leaf

100

0

1.04 ± 0.04

11.9

1.12 ± 0.10*

12.5

1.12 ± 0.06*

23.6

1.21 ± 0.04*

22.2

200

0

1.04 ± 0.07

11.9

1.14 ± 0.11*

11.0

1.13 ± 0.13*

22.6

1.23 ± 0.13*

21.2

400

0

1.08 ± 0.07

8.5

1.17 ± 0.10*

8.2

1.27 ± 0.15*

13.0

1.28 ± 0.05*

17.7

Carica papaya leaf

100

0

0.97 ± 0.03

17.8

1.04 ± 0.10*

18.4

1.15 ± 0.09**

21.2

1.10 ± 0.03**

29.3

200

0

1.10 ± 0.09

6.8

1.12 ± 0.17*

12.5

1.17 ± 0.13**

19.9

1.11 ± 0.05**

28.9

400

0

1.11 ± 0.07

6.4

1.19 ± 0.05

6.7

1.36 ± 0.11

7.2

1.32 ± 0.09*

15.1

Cymbopogon citratus leaf

100

0

1.08 ± 0.12

8.9

1.16 ± 0.04*

9.4

1.24 ± 0.11*

15.1

1.27 ± 0.03*

18.3

200

0

1.12 ± 0.04

5.1

1.17 ± 0.08*

8.2

1.20 ± 0.02*

18.2

1.34 ± 0.04*

13.8

400

0

1.15 ± 0.04

3.0

1.24 ± 0.01

3.1

1.42 ± 0.06

3.1

1.48 ± 0.09

5.1

Citrus sinensis leaf

100

0

1.15 ± 0.12

2.5

1.22 ± 0.03

4.7

1.24 ± 0.05*

15.1

1.27 ± 0.13*

18.6

200

0

1.17 ± 0.03

1.3

1.19 ± 0.04

7.1

1.35 ± 0.20

7.5

1.46 ± 0.16

6.4

400

0

1.17 ± 0.04

0.8

1.20 ± 0.03

6.3

1.45 ± 0.04

1.0

1.56 ± 0.13

0.0

Ocimum gratissimum leaf

100

0

1.06 ± 0.05

10.6

1.14 ± 0.07*

10.6

1.23 ± 0.04*

16.1

1.22 ± 0.05*

21.5

 

200

0

1.07 ± 0.06

9.3

1.16 ± 0.08*

9.4

1.23 ± 0.04*

16.1

1.24 ± 0.02*

20.3

 

400

0

1.17 ± 0.03

1.3

1.26 ± 0.04

1.2

1.31 ± 0.12

10.3

1.33 ± 0.08

14.5

  1. Significant difference: compared to control; (*)-p < 0.05, (**)-p < 0.01