Skip to main content

Table 3 Anti-inflammatory effect of the constituent plant extracts of Nefang on carrangeenan-induced paw edema in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract) Dose (mg/kg) Increase in paw volumes [PV] (mL) and edema inhibition [EI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=5\right) \)
   0 60   120   180   240  
    PV EI PV EI PV EI PV EI
Normal Saline - 0 1.18 ± 0.08 0.0 1.28 ± 0.14 0.0 1.46 ± 0.13 0.0 1.56 ± 0.09 0.0
Indomethacin 10 0 1.17 ± 0.04 1.3 1.08 ± 0.03* 15.3 1.00 ± 0.10** 31.5 0.88 ± 0.03** 43.7
Mangifera indica bark 100 0 1.07 ± 0.11 9.7 1.13 ± 0.09* 11.4 1.19 ± 0.03* 18.8 1.12 ± 0.01** 28.3
200 0 1.15 ± 0.12 3.0 1.21 ± 0.02 5.5 1.32 ± 0.06* 9.9 1.24 ± 0.10* 20.6
400 0 1.18 ± 0.05 0.4 1.27 ± 0.04 0.8 1.36 ± 0.03 6.8 1.26 ± 0.06* 19.0
Mangifera indica leaf 100 0 1.04 ± 0.13 11.9 1.01 ± 0.08* 20.8 0.92 ± 0.08** 37.3 0.93 ± 0.06** 40.2
200 0 1.05 ± 0.03 11.4 1.11 ± 0.08* 13.3 0.91 ± 0.14** 37.7 0.95 ± 0.11** 39.2
400 0 1.05 ± 0.03 11.4 0.93 ± 0.03* 27.5 0.89 ± 0.06** 39.4 0.88 ± 0.08** 43.4
Psidium guajava leaf 100 0 1.04 ± 0.04 11.9 1.12 ± 0.10* 12.5 1.12 ± 0.06* 23.6 1.21 ± 0.04* 22.2
200 0 1.04 ± 0.07 11.9 1.14 ± 0.11* 11.0 1.13 ± 0.13* 22.6 1.23 ± 0.13* 21.2
400 0 1.08 ± 0.07 8.5 1.17 ± 0.10* 8.2 1.27 ± 0.15* 13.0 1.28 ± 0.05* 17.7
Carica papaya leaf 100 0 0.97 ± 0.03 17.8 1.04 ± 0.10* 18.4 1.15 ± 0.09** 21.2 1.10 ± 0.03** 29.3
200 0 1.10 ± 0.09 6.8 1.12 ± 0.17* 12.5 1.17 ± 0.13** 19.9 1.11 ± 0.05** 28.9
400 0 1.11 ± 0.07 6.4 1.19 ± 0.05 6.7 1.36 ± 0.11 7.2 1.32 ± 0.09* 15.1
Cymbopogon citratus leaf 100 0 1.08 ± 0.12 8.9 1.16 ± 0.04* 9.4 1.24 ± 0.11* 15.1 1.27 ± 0.03* 18.3
200 0 1.12 ± 0.04 5.1 1.17 ± 0.08* 8.2 1.20 ± 0.02* 18.2 1.34 ± 0.04* 13.8
400 0 1.15 ± 0.04 3.0 1.24 ± 0.01 3.1 1.42 ± 0.06 3.1 1.48 ± 0.09 5.1
Citrus sinensis leaf 100 0 1.15 ± 0.12 2.5 1.22 ± 0.03 4.7 1.24 ± 0.05* 15.1 1.27 ± 0.13* 18.6
200 0 1.17 ± 0.03 1.3 1.19 ± 0.04 7.1 1.35 ± 0.20 7.5 1.46 ± 0.16 6.4
400 0 1.17 ± 0.04 0.8 1.20 ± 0.03 6.3 1.45 ± 0.04 1.0 1.56 ± 0.13 0.0
Ocimum gratissimum leaf 100 0 1.06 ± 0.05 10.6 1.14 ± 0.07* 10.6 1.23 ± 0.04* 16.1 1.22 ± 0.05* 21.5
  200 0 1.07 ± 0.06 9.3 1.16 ± 0.08* 9.4 1.23 ± 0.04* 16.1 1.24 ± 0.02* 20.3
  400 0 1.17 ± 0.03 1.3 1.26 ± 0.04 1.2 1.31 ± 0.12 10.3 1.33 ± 0.08 14.5
  1. Significant difference: compared to control; (*)-p < 0.05, (**)-p < 0.01