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Table 2 Effect of the aqueous extracts of the constituent plants of Nefang on Brewer’s Yeast-induced hyperpyrexia in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract) Dose (mg/kg) Basal Temperature Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes)
\( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)
    30   60   120   180   240  
    BT PI BT PI BT PI BT PI BT PI
Normal Saline - 37.00 ± 0.29 37.95 ± 0.21 0.0 38.14 ± 0.38 0.0 38.65 ± 0.32 0.0 38.91 ± 0.11 0.0 38.96 ± 0.54 0
Paracetamol 150 36.90 ± 0.38 37.70 ± 0.45 15.8 37.75 ± 0.33 25.4 37.85 ± 0.28* 42.4 37.47 ± 0.26* 70.2 37.00 ± 0.39** 94.9
Mangifera indica bark 200 36.90 ± 0.31 37.85 ± 0.39 0.0 37.90 ± 0.41 12.3 37.75 ± 0.27* 48.5 37.55 ± 0.25* 66.0 37.20 ± 0.41* 84.7
  400 36.95 ± 0.92 37.95 ± 0.27 0.0 38.15 ± 0.54 0.0 37.73 ± 0.31* 52.7 37.50 ± 0.19* 71.2 37.30 ± 0.38* 82.1
Mangifera indica leaf 200 37.00 ± 0.74 37.85 ± 0.16 10.5 37.95 ± 0.37 16.7 37.60 ± 0.18* 63.6 37.35 ± 0.11* 81.7 37.20 ± 0.28* 89.8
400 37.05 ± 0.67 38.45 ± 0.43 0.0 38.60 ± 0.29 0.0 38.25 ± 0.17* 27.3 37.90 ± 0.28* 55.5 37.50 ± 0.19* 77.0
Psidium guajava leaf 200 36.95 ± 0.51 38.00 ± 0.54 0.0 38.40 ± 0.61 0.0 38.70 ± 0.19 0.0 38.65 ± 0.38 11.0 38.50 ± 0.17 20.9
400 37.10 ± 0.33 38.00 ± 0.15 5.3 38.65 ± 0.72 0.0 38.75 ± 0.24 0.0 38.55 ± 0.36 24.1 38.45 ± 0.11 31.1
Carica papaya leaf 200 37.00 ± 0.61 38.25 ± 0.27 0.0 38.60 ± 0.36 0.0 38.68 ± 0.22 0.0 38.65 ± 0.31 13.6 38.60 ± 0.26 18.4
400 36.90 ± 0.68 37.90 ± 0.51 0.0 38.45 ± 0.29 0.0 38.65 ± 0.31 0.0 38.70 ± 0.29 5.8 38.60 13.3
Cymbopogon citratus leaf 200 36.95 ± 0.28 37.90 ± 0.89 0.0 37.85 ± 0.18 21.1 37.45 ± 0.35* 69.7 37.20 ± 0.52* 86.9 37.00 ± 0.09** 97.4
400 37.00 ± 0.41 38.05 ± 0.62 0.0 37.70 ± 0.09 38.6 37.45 ± 0.18* 72.7 37.30 ± 0.56* 84.3 37.05 ± 0.22** 97.4
Citrus sinensis leaf 200 37.00 ± 0.22 38.00 ± 0.20 0.0 38.05 ± 0.25 7.9 37.85 ± 0.26* 48.5 37.55 ± 0.19* 71.2 37.35 ± 0.35* 82.1
400 37.05 ± 0.15 38.05 ± 0.31 0.0 38.25 ± 0.18 0.0 37.75 ± 0.11* 57.6 37.45 ± 0.55* 79.1 37.25 ± 0.28* 89.8
Ocimumgratissimum leaf 200 37.00 ± 0.33 37.95 ± 0.46 0.0 37.90 ± 0.42 21.1 37.75 ± 0.19* 54.5 37.40 ± 0.38* 79.1 37.15 ± 0.52** 92.3
400 37.00 ± 0.81 37.95 ± 0.19 0.0 38.00 ± 0.19 12.3 37.75 ± 0.09* 54.5 37.45 ± 0.61* 76.4 37.10 ± 0.33** 94.9
  1. Significant difference * - p < 0.05, ** - p < 0.001 when compared to the control