|
Treatment (Drug/Aqueous Extract)
|
Dose (mg/kg)
|
Basal Temperature
|
Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)
|
|---|
| | | |
30
| |
60
| |
120
| |
180
| |
240
| |
|---|
| | | |
BT
|
PI
|
BT
|
PI
|
BT
|
PI
|
BT
|
PI
|
BT
|
PI
|
|---|
|
Normal Saline
|
-
|
34.95 ± 0.33
|
35.78 ± 0.19
|
0.0
|
36.23 ± 0.32
|
0.0
|
36.70 ± 0.38
|
0.0
|
36.78 ± 0.39
|
0.0
|
36.98 ± 0.33
|
0.0
|
|
Paracetamol
|
150
|
34.98 ± 0.42
|
35.85 ± 0.24
|
15.5
|
36.18 ± 0.28
|
15.9
|
36.08 ± 0.19*
|
37.1
|
35.28 ± 0.29*
|
78.1
|
34.98 ± 0.17**
|
100.0
|
|
Mangifera indica bark
|
200
|
35.03 ± 0.10
|
36.40 ± 0.14
|
0.0
|
35.90 ± 0.22
|
31.4
|
35.60 ± 0.16*
|
67.1
|
35.45 ± 0.13*
|
76.7
|
35.25 ± 0.33*
|
88.9
|
|
400
|
35.00 ± 0.08
|
36.55 ± 0.21
|
0.0
|
36.03 ± 0.15
|
19.6
|
35.68 ± 0.22*
|
61.4
|
35.45 ± 0.17*
|
75.3
|
35.33 ± 0.24*
|
84.0
|
|
Mangifera indica leaf
|
200
|
35.00 ± 0.18
|
36.05 ± 0.13
|
0.0
|
35.98 ± 0.19
|
23.5
|
35.75 ± 0.29*
|
57.1
|
35.43 ± 0.17*
|
76.7
|
35.25 ± 0.26*
|
87.7
|
|
400
|
35.18 ± 0.34
|
36.80 ± 0.24
|
0.0
|
36.78 ± 0.10
|
0.0
|
36.08 ± 0.10*
|
48.6
|
35.85 ± 0.45*
|
63.0
|
35.38 ± 0.37*
|
90.1
|
|
Psidium guajava leaf
|
200
|
35.18 ± 0.39
|
36.13 ± 0.26
|
0.0
|
36.35 ± 0.37
|
7.8
|
36.80 ± 0.14
|
7.1
|
36.63 ± 0.19
|
20.5
|
36.45 ± 0.06
|
37.0
|
|
400
|
35.15 ± 0.21
|
36.05 ± 0.19
|
0.0
|
36.50 ± 0.54
|
0.0
|
36.68 ± 0.13
|
12.9
|
36.40 ± 0.14
|
31.5
|
36.45 ± 0.33
|
35.8
|
|
Carica papaya leaf
|
200
|
35.05 ± 0.48
|
36.48 ± 0.61
|
0.0
|
36.53 ± 0.43
|
0.0
|
36.78 ± 0.49
|
1.4
|
36.80 ± 0.48
|
4.1
|
36.68 ± 0.39
|
19.8
|
|
400
|
35.00 ± 0.35
|
36.45 ± 0.52
|
0.0
|
36.63 ± 0.93
|
0.0
|
36.70 ± 0.22
|
2.9
|
36.75 ± 0.52
|
4.1
|
36.75 ± 0.37
|
13.6
|
|
Cymbopogon citratus leaf
|
200
|
35.05 ± 0.17
|
36.10 ± 0.08
|
0.0
|
35.88 ± 0.22
|
35.3
|
35.50 ± 0.38*
|
74.3
|
35.20 ± 0.41*
|
91.8
|
35.15 ± 0.17**
|
95.1
|
|
400
|
34.90 ± 0.29
|
35.85 ± 0.06
|
0.0
|
35.75 ± 0.25
|
33.3
|
35.43 ± 0.33*
|
70.0
|
35.23 ± 0.42*
|
82.2
|
35.20 ± 0.18**
|
85.2
|
|
Citrus sinensis leaf
|
200
|
34.90 ± 0.08
|
35.73 ± 0.13
|
0.0
|
36.05 ± 0.13
|
9.8
|
35.73 ± 0.15*
|
52.9
|
35.50 ± 0.12*
|
67.1
|
35.28 ± 0.22**
|
81.5
|
|
400
|
34.98 ± 0.15
|
35.93 ± 0.10
|
0.0
|
36.08 ± 0.28
|
13.7
|
35.88 ± 0.15*
|
48.6
|
35.58 ± 0.32*
|
67.1
|
35.33 ± 0.22**
|
82.7
|
|
Ocinum gratissimum leaf
|
200
|
34.93 ± 0.13
|
35.63 ± 0.36
|
15.1
|
35.80 ± 0.36
|
31.4
|
35.58 ± 0.36*
|
62.9
|
35.28 ± 0.66*
|
80.8
|
35.28 ± 0.71**
|
82.7
|
|
400
|
34.90 ± 0.16
|
35.95 ± 0.17
|
0.0
|
36.05 ± 0.17
|
9.8
|
35.88 ± 0.13*
|
44.3
|
35.25 ± 0.32*
|
80.8
|
35.20 ± 0.22**
|
85.2
|
- Siginificant difference * - p < 0.05. ** - p < 0.001 when compare to the control
