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Table 1 Effect of the aqueous plant extracts of the constituents of Nefang on D-amphetamine-induced pyrexia in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract)

Dose (mg/kg)

Basal Temperature

Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)

   

30

 

60

 

120

 

180

 

240

 
   

BT

PI

BT

PI

BT

PI

BT

PI

BT

PI

Normal Saline

-

34.95 ± 0.33

35.78 ± 0.19

0.0

36.23 ± 0.32

0.0

36.70 ± 0.38

0.0

36.78 ± 0.39

0.0

36.98 ± 0.33

0.0

Paracetamol

150

34.98 ± 0.42

35.85 ± 0.24

15.5

36.18 ± 0.28

15.9

36.08 ± 0.19*

37.1

35.28 ± 0.29*

78.1

34.98 ± 0.17**

100.0

Mangifera indica bark

200

35.03 ± 0.10

36.40 ± 0.14

0.0

35.90 ± 0.22

31.4

35.60 ± 0.16*

67.1

35.45 ± 0.13*

76.7

35.25 ± 0.33*

88.9

400

35.00 ± 0.08

36.55 ± 0.21

0.0

36.03 ± 0.15

19.6

35.68 ± 0.22*

61.4

35.45 ± 0.17*

75.3

35.33 ± 0.24*

84.0

Mangifera indica leaf

200

35.00 ± 0.18

36.05 ± 0.13

0.0

35.98 ± 0.19

23.5

35.75 ± 0.29*

57.1

35.43 ± 0.17*

76.7

35.25 ± 0.26*

87.7

400

35.18 ± 0.34

36.80 ± 0.24

0.0

36.78 ± 0.10

0.0

36.08 ± 0.10*

48.6

35.85 ± 0.45*

63.0

35.38 ± 0.37*

90.1

Psidium guajava leaf

200

35.18 ± 0.39

36.13 ± 0.26

0.0

36.35 ± 0.37

7.8

36.80 ± 0.14

7.1

36.63 ± 0.19

20.5

36.45 ± 0.06

37.0

400

35.15 ± 0.21

36.05 ± 0.19

0.0

36.50 ± 0.54

0.0

36.68 ± 0.13

12.9

36.40 ± 0.14

31.5

36.45 ± 0.33

35.8

Carica papaya leaf

200

35.05 ± 0.48

36.48 ± 0.61

0.0

36.53 ± 0.43

0.0

36.78 ± 0.49

1.4

36.80 ± 0.48

4.1

36.68 ± 0.39

19.8

400

35.00 ± 0.35

36.45 ± 0.52

0.0

36.63 ± 0.93

0.0

36.70 ± 0.22

2.9

36.75 ± 0.52

4.1

36.75 ± 0.37

13.6

Cymbopogon citratus leaf

200

35.05 ± 0.17

36.10 ± 0.08

0.0

35.88 ± 0.22

35.3

35.50 ± 0.38*

74.3

35.20 ± 0.41*

91.8

35.15 ± 0.17**

95.1

400

34.90 ± 0.29

35.85 ± 0.06

0.0

35.75 ± 0.25

33.3

35.43 ± 0.33*

70.0

35.23 ± 0.42*

82.2

35.20 ± 0.18**

85.2

Citrus sinensis leaf

200

34.90 ± 0.08

35.73 ± 0.13

0.0

36.05 ± 0.13

9.8

35.73 ± 0.15*

52.9

35.50 ± 0.12*

67.1

35.28 ± 0.22**

81.5

400

34.98 ± 0.15

35.93 ± 0.10

0.0

36.08 ± 0.28

13.7

35.88 ± 0.15*

48.6

35.58 ± 0.32*

67.1

35.33 ± 0.22**

82.7

Ocinum gratissimum leaf

200

34.93 ± 0.13

35.63 ± 0.36

15.1

35.80 ± 0.36

31.4

35.58 ± 0.36*

62.9

35.28 ± 0.66*

80.8

35.28 ± 0.71**

82.7

400

34.90 ± 0.16

35.95 ± 0.17

0.0

36.05 ± 0.17

9.8

35.88 ± 0.13*

44.3

35.25 ± 0.32*

80.8

35.20 ± 0.22**

85.2

  1. Siginificant difference * - p < 0.05. ** - p < 0.001 when compare to the control