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Table 1 Effect of the aqueous plant extracts of the constituents of Nefang on D-amphetamine-induced pyrexia in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract) Dose (mg/kg) Basal Temperature Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)
    30   60   120   180   240  
    BT PI BT PI BT PI BT PI BT PI
Normal Saline - 34.95 ± 0.33 35.78 ± 0.19 0.0 36.23 ± 0.32 0.0 36.70 ± 0.38 0.0 36.78 ± 0.39 0.0 36.98 ± 0.33 0.0
Paracetamol 150 34.98 ± 0.42 35.85 ± 0.24 15.5 36.18 ± 0.28 15.9 36.08 ± 0.19* 37.1 35.28 ± 0.29* 78.1 34.98 ± 0.17** 100.0
Mangifera indica bark 200 35.03 ± 0.10 36.40 ± 0.14 0.0 35.90 ± 0.22 31.4 35.60 ± 0.16* 67.1 35.45 ± 0.13* 76.7 35.25 ± 0.33* 88.9
400 35.00 ± 0.08 36.55 ± 0.21 0.0 36.03 ± 0.15 19.6 35.68 ± 0.22* 61.4 35.45 ± 0.17* 75.3 35.33 ± 0.24* 84.0
Mangifera indica leaf 200 35.00 ± 0.18 36.05 ± 0.13 0.0 35.98 ± 0.19 23.5 35.75 ± 0.29* 57.1 35.43 ± 0.17* 76.7 35.25 ± 0.26* 87.7
400 35.18 ± 0.34 36.80 ± 0.24 0.0 36.78 ± 0.10 0.0 36.08 ± 0.10* 48.6 35.85 ± 0.45* 63.0 35.38 ± 0.37* 90.1
Psidium guajava leaf 200 35.18 ± 0.39 36.13 ± 0.26 0.0 36.35 ± 0.37 7.8 36.80 ± 0.14 7.1 36.63 ± 0.19 20.5 36.45 ± 0.06 37.0
400 35.15 ± 0.21 36.05 ± 0.19 0.0 36.50 ± 0.54 0.0 36.68 ± 0.13 12.9 36.40 ± 0.14 31.5 36.45 ± 0.33 35.8
Carica papaya leaf 200 35.05 ± 0.48 36.48 ± 0.61 0.0 36.53 ± 0.43 0.0 36.78 ± 0.49 1.4 36.80 ± 0.48 4.1 36.68 ± 0.39 19.8
400 35.00 ± 0.35 36.45 ± 0.52 0.0 36.63 ± 0.93 0.0 36.70 ± 0.22 2.9 36.75 ± 0.52 4.1 36.75 ± 0.37 13.6
Cymbopogon citratus leaf 200 35.05 ± 0.17 36.10 ± 0.08 0.0 35.88 ± 0.22 35.3 35.50 ± 0.38* 74.3 35.20 ± 0.41* 91.8 35.15 ± 0.17** 95.1
400 34.90 ± 0.29 35.85 ± 0.06 0.0 35.75 ± 0.25 33.3 35.43 ± 0.33* 70.0 35.23 ± 0.42* 82.2 35.20 ± 0.18** 85.2
Citrus sinensis leaf 200 34.90 ± 0.08 35.73 ± 0.13 0.0 36.05 ± 0.13 9.8 35.73 ± 0.15* 52.9 35.50 ± 0.12* 67.1 35.28 ± 0.22** 81.5
400 34.98 ± 0.15 35.93 ± 0.10 0.0 36.08 ± 0.28 13.7 35.88 ± 0.15* 48.6 35.58 ± 0.32* 67.1 35.33 ± 0.22** 82.7
Ocinum gratissimum leaf 200 34.93 ± 0.13 35.63 ± 0.36 15.1 35.80 ± 0.36 31.4 35.58 ± 0.36* 62.9 35.28 ± 0.66* 80.8 35.28 ± 0.71** 82.7
400 34.90 ± 0.16 35.95 ± 0.17 0.0 36.05 ± 0.17 9.8 35.88 ± 0.13* 44.3 35.25 ± 0.32* 80.8 35.20 ± 0.22** 85.2
  1. Siginificant difference * - p < 0.05. ** - p < 0.001 when compare to the control