Skip to main content

Table 3 Effect of AHM and its fraction on prostaglandin E 2 -induced paw edema in rats

From: Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis

Treatment

Dose/route

Percent inhibition of edema Volume

+1 h

+2 h

+3 h

+4 h

AHM

50 mg/kg, p.o.

2.44 ± 0.29

18.58 ± 1.744***

52.25 ± 1.52***

54.186 ± 3.13***

100 mg/kg, p.o.

3.76 ± 0.176

33.31 ± 1.084***

72.86 ± 2.081***

75.19 ± 2.62***

150 mg/kg, p.o.

4.16 ± 0.176

42.50 ± 1.76***

86.72 ± 3.45***

86.11 ± 1.41***

AHE

50 mg/kg, p.o.

4.72 ± 0.355

24.16 ± 1.20***

64.34 ± 1.88***

75.68 ± 2.61***

100 mg/kg, p.o.

4.33 ± 0.12

37.77 ± 1.36***

77.21 ± 2.23***

84.12 ± 0.90***

150 mg/kg, p.o.

4.80 ± 0.152

59.338 ± 3.05***

90.57 ± 0.76***

91.345 ± 0.57***

Diclofenac sodium

10 mg/kg, i.p.

5.13 ± 0.145

55.83 ± 2.63***

87.72 ± 2.53***

88.11 ± 0.68***

  1. Data values shown represent mean ± SEM (n = 6). ***p < 0.001 versus only PGE2 treated group (Two-way ANOVA followed by Bonferroni multiple comparison test).