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Table 2 Effect of AHM and its fraction on carrageenan-induced paw edema in rats

From: Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis

Treatment Dose/route Mean paw volume before carrageenan injection Increase in paw volume (ml) after carrageenan injection (mean ± SEM)/Percent inhibition of edema
+1 h +2 h +3 h +4 h
Saline 2 ml, i.p. 1.2 ± 0.0265 2.66 ± 0.015 2.5 ± 0.095 2.24 ± 0.104 1.93 ± 0.053
AHM 50 mg/kg, p.o. 1.043 ± 0.03 2.488 ± 0.045 1.82 ± 0.062 1.56 ± 0.047 1.39 ± 0.032
(1.34 ± 0.917) (40.23 ± 0.413) (52.29 ± 3.12) (52.46 ± 2.419)
100 mg/kg, p.o. 0.89 ± 0.04 2.311 ± 0.03 1.543 ± 0.02 1.301 ± 0.015 1.156 ± 0.05
(3.11 ± 1.6) (49.41 ± 2.023) (60.47 ± 0.429*) (63.47 ± 0.457*)
150 mg/kg, p.o. 1.01 ± 0.037 2.423 ± 0.043 1.49 ± 0.07 1.27 ± 0.060 1.119 ± 0.06
(3.63 ± 1.135) (63.07 ± 0.09*) (75 ± 0.23**) (85.06 ± 1.47**)
AHE 50 mg/kg, p.o. 1.05 ± 0.05 2.473 ± 0.013 1.797 ± 0.039 1.473 ± 0.046 1.343 ± 0.029
(2.295 ± 0.10) (46.64 ± 0.63***) (69.56 ± 0.564***) (78.29 ± 1.000***)
100 mg/kg, p.o. 1.01 ± 0.29 2.307 ± 0.036 1.491 ± 0.010 1.274 ± 0.37 1.09 ± 0.51
(2.50 ± 0.20) (67.14 ± 0.500***) (81.159 ± 0.5***) (92.07 ± 1.00***)
150 mg/kg, p.o. 1.01 ± 0.5 2.403 ± 0.05 1.46 ± 0.026 1.178 ± 0.019 1.036 ± 0.036
(3.86 ± 0.428) (67.85 ± 1.00***) (87.82 ± 1.00***) (93.40 ± 1.00***)
Diclofenac sodium 10 mg/kg, i.p. 1.19 ± 0.015 2.576 ± 0.03 1.600 ± 0.02 1.426 ± 0.0305 1.27 ± 0.01
(5.52 ± 0.575) (68.46 ± 0.815**) (77.24 ± 0.192**) (89.04 ± 2.048***)
Fluoxetine 10 mg/kg, i.p. 1.09 ± 0.064 2.50 ± 0.091 1.63 ± 0.04 1.343 ± 0.055 1.192 ± 0.017
(3.86 ± 0.212) (58.461 ± 1.972*) (75.64 ± 0.093**) (85.98 ± 2.008**)
Aspirin 10 mg/kg, i.p. 1.157 ± 0.04 2.597 ± 0.032 1.736 ± 0.075 1.486 ± 0.066 1.34 ± 0.0264
(1.84 ± 0.50) (55.46 ± 0.246*) (68.30 ± 0.094**) (74.93 ± 5.15**)
  1. Data values shown represent mean ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 versus only carrageenan treated group (Two-way ANOVA followed by Bonferroni multiple comparison test). Percentage inhibition is shown in brackets. Inhibition in saline treated group at each time point was calculated relative to paw edema after 1 h.