Figure 4From: Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signalingEffects of F. mume on hippocampal expression level of inflammatory mediators in chronic BCCAo rats. (A) Representative western blots of COX-2, IL-1β, and IL-6. Densitometry was performed for COX-2, IL-1β, and IL-6 normalized to GAPDH using Image J (v1.37) software. (B through D) The expression level of the inflammatory mediators (COX-2, IL-1β, and IL-6) was increased in the BCCAo + Vehicle group (n = 10) compared to the sham-operated group (n = 8). Treatment with F. mume (n = 8) attenuated the increased level of the inflammatory mediators induced by chronic BCCAo in the hippocampus (#). Data were analyzed via ANOVA followed by the Tukey test. *, p < 0.05 versus the BCCAo + Vehicle group; #, p <0.05 versus the BCCAo + F. mume group.Back to article page