Detection of Enterodiol in Plasma. Levels of plasma enterodiol were quantitated at weeks 0, 1, 2, 4, and 8 of the trial using LC/MS/MS. No enterodiol was detected at week 0, prior to start of trial, and at week 8, which corresponds to 4 weeks after FS was discontinued. Data is presented as plasma concentration (nM). Panel A displays comparison between healthy controls (n = 5) and all cystic fibrosis patients (n = 10). Panel B displays comparison between healthy controls (n = 5), cystic fibrosis patients with low lignans (n = 6), and cystic fibrosis patients with high lignans (n = 4). * signifies p < 0.05 for comparison between any time point in each respective cohort versus baseline (pre-FS).