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Table 1 Microstructure of cancellous bone at the distal part of the left femur

From: Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model

Groups (n = 10)

BV/TV (%)

BS/BV (mm)

Tb.Th (mm)

Tb.N (mm−1)

Tb.Sp (mm)

Fractal dimension

Normal

35.02 ± 2.65

18.83 ± 3.22

0.106 ± 0.004

3.30 ± 0.23

0.20 ± 0.03

2.49 ± 0.021

Control

28.41 ± 1.47*

23.36 ± 3.15*

0.086 ± 0.004*

3.32 ± 0.74

0.22 ± 0.05

2.39 ± 0.071

MTX

33.38 ± 3.12*

19.71 ± 2.71*

0.102 ± 0.003*#

3.29 ± 0.23*#

0.20 ± 0.04

2.46 ± 0.052

Brazilin

32.53 ± 4.03*

20.23 ± 3.13*

0.099 ± 0.006*#

3.29 ± 0.21*

0.21 ± 0.02

2.41 ± 0.041

  1. Four groups of mice (n = 10 each) were evaluated: control mice without collagen-induced arthritis (CIA) (normal) and CIA mice treated with saline (control group), with therapeutic administration of methotrexate (MTX: 3 mg/kg of body weight; injected every third day from day 22 to day 42 after 2nd booster injection) or brazilin (10 mg/kg of body weight; injected daily from day 22 to day 42 after the 2nd booster injection). BV - bone volume; TV - tissue volume; BS - bone surface; Tb.Th - trabecular thickness; Tb.N - trabecular number; Tb.Sp - trabecular separation; *p < 0.05 versus normal group. #p < 0.05 versus control group.