Groups (n = 10) | BV/TV (%) | BS/BV (mm) | Tb.Th (mm) | Tb.N (mm−1) | Tb.Sp (mm) | Fractal dimension |
---|
Normal
| 35.02 ± 2.65 | 18.83 ± 3.22 | 0.106 ± 0.004 | 3.30 ± 0.23 | 0.20 ± 0.03 | 2.49 ± 0.021 |
Control
| 28.41 ± 1.47* | 23.36 ± 3.15* | 0.086 ± 0.004* | 3.32 ± 0.74 | 0.22 ± 0.05 | 2.39 ± 0.071 |
MTX
| 33.38 ± 3.12* | 19.71 ± 2.71* | 0.102 ± 0.003*# | 3.29 ± 0.23*# | 0.20 ± 0.04 | 2.46 ± 0.052 |
Brazilin
| 32.53 ± 4.03* | 20.23 ± 3.13* | 0.099 ± 0.006*# | 3.29 ± 0.21* | 0.21 ± 0.02 | 2.41 ± 0.041 |
- Four groups of mice (n = 10 each) were evaluated: control mice without collagen-induced arthritis (CIA) (normal) and CIA mice treated with saline (control group), with therapeutic administration of methotrexate (MTX: 3 mg/kg of body weight; injected every third day from day 22 to day 42 after 2nd booster injection) or brazilin (10 mg/kg of body weight; injected daily from day 22 to day 42 after the 2nd booster injection). BV - bone volume; TV - tissue volume; BS - bone surface; Tb.Th - trabecular thickness; Tb.N - trabecular number; Tb.Sp - trabecular separation; *p < 0.05 versus normal group. #p < 0.05 versus control group.