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Table 1 Microstructure of cancellous bone at the distal part of the left femur

From: Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model

Groups (n = 10) BV/TV (%) BS/BV (mm) Tb.Th (mm) Tb.N (mm−1) Tb.Sp (mm) Fractal dimension
Normal 35.02 ± 2.65 18.83 ± 3.22 0.106 ± 0.004 3.30 ± 0.23 0.20 ± 0.03 2.49 ± 0.021
Control 28.41 ± 1.47* 23.36 ± 3.15* 0.086 ± 0.004* 3.32 ± 0.74 0.22 ± 0.05 2.39 ± 0.071
MTX 33.38 ± 3.12* 19.71 ± 2.71* 0.102 ± 0.003*# 3.29 ± 0.23*# 0.20 ± 0.04 2.46 ± 0.052
Brazilin 32.53 ± 4.03* 20.23 ± 3.13* 0.099 ± 0.006*# 3.29 ± 0.21* 0.21 ± 0.02 2.41 ± 0.041
  1. Four groups of mice (n = 10 each) were evaluated: control mice without collagen-induced arthritis (CIA) (normal) and CIA mice treated with saline (control group), with therapeutic administration of methotrexate (MTX: 3 mg/kg of body weight; injected every third day from day 22 to day 42 after 2nd booster injection) or brazilin (10 mg/kg of body weight; injected daily from day 22 to day 42 after the 2nd booster injection). BV - bone volume; TV - tissue volume; BS - bone surface; Tb.Th - trabecular thickness; Tb.N - trabecular number; Tb.Sp - trabecular separation; *p < 0.05 versus normal group. #p < 0.05 versus control group.