Large dose means significant effect – dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats

Table 4 Effect of CDTHD on histopathological changes in rat liver obtained at 48 h after ANIT administration (n = 10)

Group	Hepatocyte hydropic degeneration	Hepatocellular necrosis	Sinusoid enlargement	Inflammatory cells infiltration
N	-	-	-	-
M	++	+++	+	++
A	++	+	+	+
B	++	+	-	-
C	-	+	-	-
D	-	-	-	-
E	-	-	-	-
F	-	-	-	+
G	-	-	-	-

Data were expressed as the mean of ten specimens for each group. + Mild, ++ Moderate, +++ Marked, − Negative. N: Normal, M: Model, A: 5.4 g/kg CDTHD, B: 10.8 g/kg CDTHD, C: 21.6 g/kg CDTHD, D: 43.2 g/kg CDTHD, E: 86.4 g/kg CDTHD, F: 35.1 g/kg CDTHD, G: 62.1 g/kg CDTHD.

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