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Table 2 Effect of bitter melon (ucche) on biochemical parameter in plasma and liver

From: Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats

Parameters Groups pvalues
Control Control + Ucche CCl4 CCl4 + Ucche CCl4 Treatment Interaction
Plasma    
AST(U/L) 19.0 ± 1.6 21.32 ± 1.68 37.9 ± 3.1 23.3 ± 4.0 0.0374 0.0012 0.0062
ALT(U/L) 13.8 ± 1.7 16.59 ± 2.62 30.5 ± 3.1 18.7 ± 1.9 0.0831 0.0012 0.0082
ALP(U/L) 50.8 ± 3.3 50.92 ± 2.76 81.2 ± 6.1 63.9 ± 4.7 0.0731 0.0001 0.0690
MDA(nmol/mL) 6.34 ± 0.37 3.57 ± 0.54 7.7 ± 0.91 6.71 ± 0.77 0.0731 0.0001 0.0690
NO (nmol/mL) 3.22 ± 0.27 2.24 ± 0.22 5.8 ± 0.3 1.15 ± 0.32 <0.0001 0.0195 <0.0001
APOP (nmol/mL equivalent to Chloramine-T) 82.60 ± 8.49 67.0 ± 9.2 164.4 ± 15.15 84.3 ± 8.8 0.0340 0.0102 0.3072
Catalase (U/min) 6.00 ± 0.32 4.28 ± 0.38 2.93 ± 0.60 5.07 ± 0.74 0.6960 0.0343 0.0011
GSH (ng/mg protein) 20.05 ± 1.81 18.39 ± 1.03 12.72 ± 0.57 16.39 ± 0.57 0.3788 0.0005 0.0270
Liver    
AST(U/L) 36.18 ± 3.22 31.01 ± 3.46 65.18 ± 3.87 46.51 ± 2.11 0.0023 <0.0001 0.0594
ALT(U/L) 26.00 ± 3.88 34.67 ± 2.24 77.61 ± 4.80 28.77 ± 1.49 <0.0001 <0.0001 <0.0001
ALP(U/L) 30.33 ± 3.67 31.42 ± 3.54 113.53 ± 3.71 68.25 ± 3.67 <0.0001 <0.0001 <0.0001
NO (nmol/mL) 15.87 ± 1.56 20.21 ± 0.45 35.62 ± 4.21 18.11 ± 2.17 0.0225 0.0036 0.0006
MDA (nmol/mL) 21.85 ± 1.86 24.62 ± 4.88 57.16 ± 6.44 36.92 ± 1.98 0.0741 <0.0001 0.0226
APOP (nmol/mL equivalent to Chloramine-T) 365.00 ± 40.19 450.0 ± 75.83 1357.62 ± 91.06 977.50 ± 63.05 0.0491 < 0.0001 0.0097
Catalase (U/min) 52.13 ± 4.02 68.40 ± 5.92 26.32 ± 3.82 50.27 ± 2.33 0.0003 < 0.0001 0.3967
GSH (ng/mg protein) 21.22 ± 1.91 19.22 ± 1.13 45.98 ± 5.05 32.89 ± 1.79 0.0171 < 0.0001 0.0703
  1. Values are presented as mean ± SEM. N = 5-6 in each group or otherwise specified. Two way or One way ANOVA with Bonferoni tests were done as post hoc test. Values are considered significance at p < 0.05. a vs b, control vs CCl4; b vs c, CCl4 vs ucche treatment. APOP-Advanced protein oxidation product, expressed as nmol/mL equivalent to Chloramine-T.