Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats

Table 1 Effect of bitter melon (Ucche) on body weight, food and water intake and organ weight of CCl ₄ treated rats

Parameters	Control	Control + Ucche	CCl₄	CCl₄ + Ucche	pvalues
Parameters	Control	Control + Ucche	CCl₄	CCl₄ + Ucche	CCl₄	Treatment	Interaction
Initial Body weight	144.15 ± 4.65	146.93 ± 4.51	155.67 ± 7.13	133.14 ± 3.19	0.0752	0.8310	0.0261
Final Body weight	175.83 ± 1.90	147.00 ± 3.81	146.68 ± 8.33	133.90 ± 5.89	0.0013	0.0012	0.1630
Food intake/d	17.8 ± 0.64	14.75 ± 0.60	11.08 ± 0.46	16.74 ± 0.81	0.0013	0.0509	<0.0001
Water intake/d	20.58 ± 0.77	16.94 ± 0.89	11.80 ± 0.41	13.72 ± 0.54	0.7271	0.0722	0.7751
Liver wet weight	6.09 ± 0.36	5.25 ± 0.10	5.62 ± 0.25	4.93 ± 0.47	<0.0001	0.2282	0.0134
Kidney wet weight	1.04 ± 0.07	0.95 ± 0.03	0.86 ± 0.04	0.71 ± 0.19	0.5910	<0.0001	0.9141
Heart wet weight	0.42 ± 0.02	0.46 ± 0.01	0.52 ± 0.01	0.45 ± 0.05	0.1995	<0.0001	0.1995
Spleen wet weight	0.49 ± 0.06	0.58 ± 0.02	0.81 ± 0.09	0.58 ± 0.04	<0.0001	0.3009	0.0067

Values are presented as mean ± SEM. N = 5-7 in each group or otherwise specified. Two way or One way ANOVA with Bonferoni tests were done as post hoc test. Values are considered significance at p < 0.05. a vs b, control vs CCl₄; b vs c, CCl₄ vs ucche treatment.

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